Teijin Limited

Nippon Infrared Industries Co., Ltd.

Teljin Limited

Kunio Sekine

Yoshiki Suzuki

Gentaro Yamashita

Hisao Yamaguchi

Norihiro Suenaga

Tsuneji Nagai

Nobuyuki Suenaga

Michihiro Kaneda

Kiichiro Shinokura

Yuji Nishimoto

Naoki Nambu

Daisuke Araki

An intranasally applicable powdery pharmaceutical composition comprising a polypeptide having a physiological activity, a quaternary ammonium compound, and a lower alkyl ether of cellulose. This powdery pharmaceutical composition has an excellent preservability and chemical stability of the polypeptides and, when the powdery composition is administered to the nasal cavity in the form of a spray, the polypeptides are effectively absorbed through the nasal mucosa.

Intranasally applicable powdery pharmaceutical composition

What is provided by this invention is a powdery pharmaceutical composition for nasal administration comprising physiologically active polypeptide or its derivative such as calcitonin, insulin, etc. and a water-absorbing and water-insoluble base. The pharmaceutical composition allows polypeptide or its derivative to be efficiently absorbed through the nasal macous membrane when it is nasally administered.

Powdery pharmaceutical composition for nasal administration

Laser irradiating apparatus equipped with a vertical shaft fixed on a power supply box, a first arm which slides up and down along the shaft and rotates around the shaft and a second arm which is pivoted at the first arm tip portion, and with a laser head installed on the second arm. In this apparatus, an articulated arm light guide is fixed on the upper side of the laser head tip portion. Variation of positions of the first and second arms provides a wide range for operation and much compactness of the apparatus when storing. In addition, the laser head is soundly installed on the second arm upper surface, which is useful to prevent any optical deviation.

Laser irradiating apparatus

A pharmaceutical composition for intrarectal administration comprising a pharmaceutically effective amount of an active ingredient which when administered alone to the rectum, is substantially unabsorbable into the living body through the mucous membrane of the rectum, said composition further containing an absorption aid acting within the rectum in such a way as to induce absorption of said active ingredient through the rectal mucous membrane, said absorption aid being characterized by (1) being substantially nontoxic to living organisms, (2) containing in the molecule at least two hydrophilic groups selected from the class consisting of carboxyl groups, acidic hydroxyl groups, carboxyl groups in the form of pharmaceutically acceptable salts, acidic hydroxyl groups in the form of pharmaceutically acceptable salts, carboxyl groups in the form of amides and acidic hydroxyl groups in the form of esters, (3) containing in the molecule at least two lipophilic groups selected from the class consisting of groups of the formulae ##STR1## and -CH.sub.2 -, the number of the lipophilic groups being not less than that of the hydrophilic groups, and (4) having a molecular weight of from about 100 to about 300; and a suppository prepared therefrom in unit dosage form.

Pharmaceutical composition for intrarectal administration, and

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Hino, Japan

Kunio Sekine