Mitsui Toatsu Chemicals, Incorporated

Kunio Sannohe

Joji Kamiya

Takafumi Kitano

Makoto Hirayama

Masahiko Maruyama

Tadahito Nobori

Akira Awaya

Tsuneji Suzuki

Haruki Mori

Nobuya Kawauchi

Tatsuro Yokoyama

Kengo Otsuka

Tsutomu Katakami

Michihiko Miyamoto

Masaaki Ishii

Toshihiko Ito

Kanji Yoshihara

Toshohiko Ito

A pyrimidinedione derivative compound has a basic backbone in which a phenyl group part and a pyrimidinedione part are linked by a structure comprising an alkyl chain containing at least two nitrogen atoms. The pyrimidinedione derivative is useful for a medical treatment of cardiac arrhythmias.

Pyrimidinedione compounds, method of producing the same and

An isoquinoline derivative of the following formula: ##STR1## wherein R.sub.1 is a methyl or a methoxymethyl group and R.sub.2 and R.sub.3 are each a hydrogen atom or a methyl, ethyl, methoxy, a cyclohexyl, a phenyl, a 3,4-dimethoxyphenyl, a pyridyl or an oxo (.dbd.O) group; and therapeutically acceptable salts thereof which exhibit a low toxicity and a wide range of safety and are highly useful as a cardiotonic medication.

Isoquinoline derivative

Isoquinoline derivatives represented by the general formula (I): ##STR1## wherein R.sub.1 denotes a hydrogen or halogen atom, or a nitro or acetyl group, and R.sub.2 denotes a hydrogen atom, or a methyl, methoxy, phenyl, 4-pyridyl or 2-pyridyl group, and therapeutically acceptable salts thereof have high cardiotonic activity and low toxicity.

Isoquinoline derivatives

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Kanagawa, Japan

Kunio Sannohe