Mitsui Toatsu Chemicals, Incorporated

Kunio Okumura

Hiroyuki Yamashita

Hajime Iizuka

Norio Ohto

Hiroshi Kawazura

Seitaro Kajiya

Junya Fujiwara

Yoshio Shiga

Kouhei Yazawa

Yasuhiro Takahashi

Toshiyuki Shimazaki

Kenji Kibayashi

Michihiko Miyamoto

Yuki Nakajima

Yoji Aoki

Akihito Kanematsu

Isao Yokoyama

Takanori Yutaka

The invention relates to a substituted amidine derivative which has an excellent platelet aggregation inhibiting action on the basis of fibrinogen antagonism and is particularly excellent in effectiveness on oral administration, and the platelet aggregation inhibitor containing the substituted amidine derivative of the invention as an effective ingredient is effective for prevention and treatment of thrombosis, and restenosis or reocclusion after percutaneous transluminal coronary angioplasty or percutaneous transluminal coronary recanalization.

Amidine derivatives and platelet aggregation inhibitor containing the

The invention relates to a novel compound which is represented by the formula (1) and has an excellent platelet aggregation inhibiting action based on fibrinogen antagonism. The platelet aggregation inhibitor containing the compound of the formula (1) as an effective ingredient are effective for prevention and curing of thrombosis and restenosis or reocclusion after percutaneous transluminal coronary angioplasty or percutaneous transluminal coronary recanalization.

Bicyclic compound and platelet aggregation inhibitor containing the same

The present invention relates to a novel (-)-2-pyrazoline compound and therapeutic agents containing the same as an effective ingredient; furthermore, it relates to a method for optically resolving 1-(3-pyridylcarbonyl)-5-methyl-2-pyrazoline.

(-)-2-pyrazoline compounds and therapeutic agent for cerebrovascular

Method of optically resolving

1-Acyl-2-pyrazoline derivatives represented by the formula ##STR1## where R.sup.1 denotes a hydrogen atom, pyridyl group, pyrazinyl group, alkyl group, aryl group, or alkoxy group; and R.sup.2, R.sup.3, and R.sup.4 independently denote a hydrogen atom, furyl group, pyridyl group, alkyl group, or aryl group, are produced by cyclizing by heating an acylhydrazone derivative represented by the formula ##STR2## where R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are defined as above, to produce compounds having useful anti-cerebral edema activity.

Process for producing 1-acyl-2-pyrazoline derivative

Growing community of inventors

Kamakura, Japan

Kunio Okumura