Chugai Seiyaku Kabushiki Kaisha

Maruha Corporation

Kunio Ogasawara

Keisuke Yamamoto

Yoshiaki Kato

Takashi Emura

Akira Kawase

Masazumi Nishikawa

Koji Takano

Tadakazu Tamai

Itsuki Murota

Kazuyoshi Yoshikai

Michiyasu Takahashi

There are provided a novel process for producing [{(5Z,7E)-(1S,3R,20S)-1,3-dihydroxy-9,10-secopregna-5,7,10(19),16-tetraen-20-yl}oxy]-N-(2,2,3,3,3-pentafluoropropyl)acetamide, which process is shown in the following reaction scheme: an intermediate useful for carrying out the process, and a process for producing the intermediate.

Process for producing vitamin D derivative using convergent method

The present invention relates to aliphatic compounds of the formula I, or stereoisomers thereof, or their pharmaceutically acceptable salts:wherein A represents an optionally substituted CHCH&#x2014; (wherein n denotes an integer of 4 to 22, and m represents an unsaturation number which is an integer of 0 to 7), l represents an integer of 0 to 10, s represents 0 or 1, provided that when s is 0, p+q=4 or 5, but when s is 1, p+q=3 or 4, and in each case, either p or q is an integer of 1 or more, R represents an alkyl group having 1 to 10 carbon atoms which may be straight-chain or branched-chain, and Rrepresents hydrogen or an alkyl group having 1 to 10 carbon atoms which may be straight-chain or branched-chain, and their use in suppression of platelet aggregation, in suppression of inflammation, and in prevention and treatment of circulatory diseases.

Aliphatic compounds, their synthesis method, and utilization of the same

Intermediate compounds in the synthesis of the A ring moiety of 2-substituted vitamin D derivatives

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Miyagi, Japan

Kunio Ogasawara