Kyowa Hakko Kogyo Co., Ltd.

Kyowa Hakko Kirin Co., Limited

Kunio Ito

Eiji Hayakawa

Kiyoshi Morimoto

Yasushi Watanabe

Sanji Tokuno

Motohiro Ohta

Yasuki Kato

Shigemitsu Miura

Yuji Kawaguchi

Junichi Miyabe

Yuji Iwase

Hiroyuki Morimoto

Hiroko Kusano

Masahiro Yamauchi

Yasuhiro Ishikawa

Kuniaki Sakato

Yoichiro Yotsuya

Tomohiko Goto

Toshiyuki Oota

Nobuhito Ashikawa

Yutaka Tomoda

Kenji Iwata

Toshihito Hosokawa

An intrabuccally rapidly disintegrating tablet which is manufactured by a simple method, has an enough practical hardness and is rapidly disintegrated in the buccal cavity and its production method. The intrabuccally rapidly disintegrating tablet is produced by growing a powder material into a granulated material with a fixed particle diameter, the powder material including a sugar alcohol or a saccharide as main ingredient, each of which is first particle having an average particle diameter of not more than 30 &#x3bc;m, by mixing thus obtained granulated material with an active ingredient and a disintegrant, and by compressing the mixture into a predetermined shape.

Intrabuccally rapidly disintegrating tablet and a production method of the tablets

The present invention provides a pharmaceutical preparation comprising a compound which can be obtained by reacting a compound having a free amino group with a sugar having the reducing power. The preparation is capable of improving the in vivo durability of various compounds and releasing the compounds in response to changes in pH, and thus is useful for causing the compounds to act specifically on target parts.

Medicinal preparations

According to the tablet production method of the present invention, tablet is produced by compressing molding material by means of punches and dies comprising the steps of using powdered or granular material including compound which is denaturalized or inactivated when tabletted at high pressure is used as the molding material, housing the punches and the dies in a spraying chamber, generating pulsating vibration air and spraying lubricant mixed in air in the spraying chamber, applying the lubricant on the surfaces of the punches and the dies while the lubricant sprayed in the spraying chamber is mixed with the pulsating vibration air, and tabletting the molding material by means of the punches applied with the lubricant on the surface thereof and the dies applied with the lubricant on the surface thereof.

Tablet manufacturing method and tablet

A press-through pack and a sealing sheet for use in the same capable of easily taking out solid material such as tablet or the like contained storage recesses by only pushing action of fingers. The pack comprises an accommodation body ( ) with plural storage recesses ( ) defined by sheet like portions ( ) for a containing solid material therein and sealing sheet ( ). The sealing sheet ( ) is made of such material that a recess ( ) in which solid material (T) contained, is partly ruptured without causing floating and peeling at the adhesion portion of the adhesive layer ( ) and the sheet like portions ( ) when pushing the projecting portion ( ) of the outer side of the recess ( ) with fingers, whereby the solid material (T) contained in the recess ( ) is easily taken out and the sealing sheet is partially bonded to the accommodation body at sheet like portions ( ) in a manner that the whole parts of sealing sheet ( ) is easily peeled off from the accommodation body.

Press-through pack, sealing sheet for press-through pack, and preparation method of tablet

An aqueous solution of a pyrazoloacridone compound or pharmaceutical salt is stabilized using an acid, placing the solution in a well-closed container, evacuating air in the container, and sealing the container.

Method of stabilizing aqueous pyrazoloacridone derivative solution

A method for producing tablet including active component, diluting agent, and lubricant by means of a tabletting machine provided with punches and dies, comprising steps of; preparing molding material including active component, diluting anent, and a part of lubricant; applying most of the remaining amount of the lubricant on surfaces of the punches and a surface of the die; and tabletting the molding material by means of the punches on which surfaces the lubricant is applied and the die on which surface the lubricant is applied

Process for the production of tablets and tablets

A dividable tablet is not chipped, can be divided easily and accurately, has excellent impact resistance and rarely causes twining in the film-coating step, wherein a dividing line is formed along a center line on the upper surface of the tablet, ridgelines are each located on an inner side of the peripheral portion of the tablet to surround the dividing line in two areas defined by the dividing line on the upper surface of the tablet, the lower surface of the tablet gradually rises from the peripheral portion of the tablet toward the center portion thereof, and areas around the ridgelines are each formed by a convex surface.

Dividable tablet and press-through pack

The present invention provides a tablet containing isotope-labeled urea and an inorganic compound.

Isotopic urea tablets

An oil-in-water emulsion containing a xanthine derivative represented by

Fat emulsion containing xanthine derivative

The present inventions provides a liposome preparation characterized by encapsulating indolocarbazole derivatives represented by formula (I): ##STR1## (wherein R represents hydrogen or lower alkyl) into a liposome comprising lipids.

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Shizuoka, Japan

Kunio Ito