Hitachi, Ltd.

Hitachi-high-technologies Corporation

Hitachi Chemical Company, Ltd.

Hitachi High-tech Corporation

Kunio Harada

Yoshitoshi Ito

Hironori Ueki

Shin-ichiro Umemura

Miyuki Kono

Takafumi Miyatake

Hideki Kambara

Sakuichiro Adachi

Masao Kamahori

Hideo Enoki

Sumio Yamaguchi

Isao Yamazaki

Sukeyoshi Tsunekawa

Tomoharu Kajiyama

Hironobu Yamakawa

Kenichi Takeda

Tomonori Mimura

Motohiro Yamazaki

Takashi Anazawa

Tatemi Ido

Tatsuo Nakagawa

Atsushi Takahashi

Tsuyoshi Sonehara

Yuzuru Shimazaki

Junko Tanaka

Hiroshi Kawazoe

Mayu Aoki

Shigeo Kubota

Tomoyuki Kamata

Yasunari Sohda

Toshimitsu Kaku

Kan Yasui

Keizo Suzuki

Tetsuo Ono

Takashi Ohshima

Hiroshi Tsuji

Hideyuki Noda

Masahiko Sato

Kazunori Okano

Yoshio Watanabe

Yoshio Kawamura

Hiroshi Kanda

Masahiro Ojima

Seiichi Murayama

Souichi Katagiri

Isao Ishikawa

Yoshiaki Yazawa

Tatsumi Mizutani

Satoshi Ozawa

Yuzuru Ohji

Hideo Morishita

Itaru Yanagi

Ui Yamaguchi

Shinichi Fukuzono

Hidetoshi Satoh

Yu Ishige

Yoshitaka Kodama

Masahiro Okanojo

Yoshinobu Kohara

Masaharu Kiyama

Masuo Kasai

Yasuo Kato

Hideo Komatsu

Tetsuyoshi Ono

Atsushi Kishioka

Shinya Iida

Haruyoshi Yamamoto

Minami Shouji

Masayuki Nagasawa

Susumu Hiraoka

Yuusuke Oominami

Sakae Saito

Norio Kanai

Nobuhiro Tsukada

Satoshi Osabe

Takeshi Fujita

Takahumi Miyatake

Mituhiro Tachibana

A digital PCR measuring apparatus capable of measuring a melting curve with high accuracy is provided. The digital PCR measuring apparatus includes a temperature adjuster that controls a temperature of a sample container including a plurality of minute regions, a fluorescence measurement part that measures fluorescence intensity of a plurality of minute regions, and a controller that controls the temperature adjuster and the fluorescence measurement part. The controller controls the temperature adjuster to raise a temperature of the sample container, and, after removing air bubbles generated in the sample container, measures fluorescence intensity of a plurality of minute regions while controlling the temperature adjuster to lower the temperature of the sample container, and measures a melting curve of a plurality of the minute regions.

Digital PCR measuring device

The present invention addresses the problem of providing a novel digital PCR analysis method. One embodiment of the novel digital PCR analysis method is a DNA detection method including the steps of: partitioning a DNA solution containing a fluorescent-labeled probe or a DNA intercalator and a target DNA to be detected into a plurality of compartments; carrying out a nucleic acid amplification reaction in the compartments; measuring a fluorescence intensity in association with a temperature change; calculating a melting temperature of a DNA double strand based on a change in the fluorescence intensity in association with the temperature change; and calculating a ratio of a fluorescence intensity at a second temperature that is lower than a first temperature in association with the temperature change to that at the first temperature.

Method and device for digital PCR measurement

A method includes a step of introducing a solution between a substrate with a membrane in which the membrane is provided so as to close an opening and a substrate provided with an independent electrode in which the independent electrode is provided, a step of pressure bonding the substrate with the membrane and the substrate with the independent electrode through a partition wall, and a step of forming a sealed liquid tank surrounded by at least the membrane and the partition wall by the pressure bonding, and arraying of a solid-state type nanopore sequencer is simply performed.

Liquid tank formation method, measurement device, and analysis device

An automated analyzer includes a plurality of measurement units including a measurement section which measures a sample, a suction container connected to the plurality of measurement units through a first path, a vacuum exhaust system connected to the suction container through a second path, a discharge section connected to the suction container through a third path, a pressure adjustment mechanism disposed in the second path, and a control section which performs control such that the suction container is vacuum-exhausted by the vacuum exhaust system.

Automated analyzer and liquid discharge method for automated analyzer

In order to provide a piston and a syringe with good sliding performance and pressure resistance performance, the piston contained in the syringe that pressurizes or decompresses an internal medium is configured such that a soft portion made of a soft material and a rigid portion made of a material having rigidity higher than rigidity of the soft portion, are connected in series, and arranged such that the soft portion is in contact with the medium and the rigid portion is not in contact with the medium. The soft portion includes a hollow on a surface in contact with the medium. The rigid portion has an end surface facing the soft portion, the end surface including at least an outer peripheral portion in contact with the soft portion. The outer diameter of the soft portion is larger than the outer diameter of the rigid portion, and the outer diameter of the rigid portion is slightly smaller than the inner diameter of an outer cylinder of the syringe.

Piston and syringe

A biological sample analysis chip including a first substrate, a membrane disposed on the first substrate, a first liquid tank which is provided with a first electrode, a plurality of second liquid tanks each of which is provided with at least one flow path and a second electrode; and a second substrate disposed below the first substrate, in which the plurality of second liquid tanks are substantially insulated from each other, the membrane disposed on the first substrate is disposed between the first liquid tank and the plurality of second liquid tanks so as to form a portion of the first liquid tank and a portion of the plurality of second liquid tanks, and the second substrate is provided with the at least one flow path and the second electrode so as to form a portion of the plurality of second liquid tanks.

Biological sample analysis chip, biological sample analyzer and biological sample analysis method

A laser beamirradiated from a side face of a microchipin which plural channelsfill ed with a member of a refractive index nin an inner portion of a member of a refractive index n(n&#x3c;n) are arranged in parallel with the same plane, along the same plane is refracted in a direction of being directed from an upper base to a lower base in a case where a section of the channelis configured by a trapezoidal shape of upper base&#x3e;lower base, and is deviated swiftly from a channel array. Hence, the laser beamis made to be deviated gradually from the channel array by irradiating the laser beamfrom the side face of the microchipby being inclined relative to the same plane in a direction of being directed from the lower base to the upper base. As a result, a larger number of the channelscan efficiently be subjected to laser beam irradiation.

Multichannel analysis device

The objective of the present invention is to simply perform image observation through transmitted charged particles. A sample irradiated by a charged particle beam is disposed directly or via a predetermined member on a light-emitting element () whereinto charged particles that have traversed or scattered inside the sample enter, causing a light to be emitted therefrom, which is collected and detected efficiently using a light transmission means () to generate a transmission charged particle image of the sample.

Sample holder with light emitting and transferring elements for a charged particle beam apparatus

It has been difficult to conduct high-sensitivity, high-precision measurement due to externally generated contamination or cross-contamination. Thus, the invention includes (1) a filter unit having a filter at a bottom of a container for holding a liquid, the filter being adapted to filter a liquid, and (2) an attachment cover having a first opening and a second opening, the filter unit being attachable to and detachable from the attachment cover via the first opening, and the attachment cover being adapted to, when the filter unit is attached to the attachment cover, allow filtration by the filter in a state in which an inner face of the attachment cover is tightly in contact with an outer face of the filter unit, and discharge a resulting filtrate through the second opening.

Filtering member and filtering method

A personal identification system, which uses a vein pattern of a finger, optimizes the amount of light of a light source based on a captured finger image and emphasizes the vein pattern during image processing for identification.

Personal identification system

Using an LED element as a light source, a photometric unit including the light source, a light receiving element and other components therebetween is reduced in size. A holderdetachable from the device as a unit holds a light emission unitformed of an LED and a light receiving element, and the holder is placed inside a thermostatic chamberwhich holds a constant temperature fluid. Thus, the photometric unit is reduced in size.

Sample analysis device

In an analysis system for detecting amounts of components contained in samples, many samples can be measured simultaneously in the whole of the system by use of compact inexpensive photometers. An LED with low heat generation and a long life span is used as a light source. Compactness is achieved by bended optical axis instead of a straight one. Components for bending an optical axis and components for condensing light to ensure an amount of light are in common use to reduce the number of components. Compactness, reduction of the number of components, and integration achieve easy optical axis alignment and precise measurement.

Photometer and analyzing system provided with photometer

Growing community of inventors

Hachioji, Japan

Kunio Harada