Sagami Chemical Research Center

Tama Biochemical Co., Ltd.

Bal Planning Co., Ltd.

Sumitomo Pharmaceuticals Company Limited

Fmc Corporation

Aventis Pharma S.a.

Lederle (japan), Ltd.

Kunikazu Sakai

Yasuo Kamuro

Hiroki Kuriyama

Tsuyoshi Watanabe

Kiyoshi Kondo

Shiro Terashima

Tamejiro Hiyama

Suguru Takatsuto

Tamotsu Fujisawa

Yoshikazu Kimura

Yoshio Ito

Makoto Sunagawa

Kiyosi Kondo

Daiei Tunemoto

Kyoko Takahashi

Akira Sasaki

Minoru Suda

Katsumi Tamoto

Yusuke Satoh

Takeo Kobori

Takeo Kawabata

Akira Kurebayashi

Barbituric acid derivative and preventive and therapeutic agent for bone and cartilage containing the same

Plant growth accelerator

The present invention relates to a plant growth regulator comprising as an active ingredient an epoxycyclohexane derivative represented by general formula (1): ##STR1## wherein R.sup.1 is a hydrogen atom, a C.sub.1 -C.sub.6 alkyl group or C.sub.3 -C.sub.6 cycloalkyl group, and R.sup.2 and R.sup.3 are independently C.sub.1 -C.sub.6 alkyl groups or are combined to form a C.sub.2 -C.sub.3 polymethylene group which may be substituted with a C.sub.1 -C.sub.6 alkyl group, as well as to a plant growth regulator comprising the epoxycyclohexane derivative and a brassinosteroid as active ingredients. The epoxycyclohexane derivatives exhibit a potent plant growth regulating action which is equivalent to or higher than that of abscisic acid, and are useful as plant growth regulators such as a plant growth accelerator, a germination growth accelerator, a transpiration and wilting inhibitor, a cold resistance enhancer, an accelerator for growing, thickening or maturing fruits, roots, stems or bulbs, etc. A synergistic effect is achieved by combination of the epoxycyclohexane derivative with a brassinosteroid.

Plant growth regulating composition comprising epoxycyclohexane

Epoxycyclohexane derivative and plant growth regulator

Optically active epoxycyclohexane derivative and epoxycyclohexanone

A compound of the formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each a hydrogen atom, a lower alkyl group, an ar(lower)alkyl group or an aryl group, or R.sub.1 and R.sub.2 may be combined together to form a lower alkylene group and/or R.sub.3 and R.sub.4 are combined together to form a lower alkylene group, or R.sub.1, R.sub.2, R.sub.3 and R.sub.4 may be combined together to form an o-phenylene group, X is a halogen atom and Y is an oxygen atom or a nitrogen atom substituted with lower alkyl or aryl, which is useful as an intermediate in the synthesis of 1.beta.-methylcarbapenem compounds valuable as antibiotics.

Heterocyclic compounds and their production

An amino acid derivative of the formula: ##STR1## wherein R.sup.1 is a protective group for hydroxyl, which is useful as an intermediate for production of antimicrobial agent.

Amino acid derivatives, and their production

A method for preparing a 5-mercapto-1,2,3-thiadiazole salt represented by the general formula (I) is disclosed: ##STR1## the method comprises the steps of: providing a sulfonylhydrazone derivative represented by the general formula (II): ##STR2## providing a sulfide represented by the general formula (III):

Method for preparing 5-mercapto-1,2,3-thiadiazole salts

Compounds of the general formula ##STR1## their method of preparation, and their use to control nematodes in agricultural crops are disclosed and exemplified.

1-(Aryl)thiocarbamoyl-2-(aryl)-3-pyrazolidinones and their nematicidal

Process for the preparation of a series of thiophene derivatives, from which 2-thiopheneacetic acid derivatives can easily be prepared, in high yields and selectivity by using substituted or unsubstituted 2-acetylthiophenes as the starting materials by easy operations. 2-Thiopheneacetic acid derivatives are very useful compounds as the chemical modifier of penicillin and cephalosporin. In the course of the reaction, 2-(dihaloacetyl)thiophenes are formed which are valuable intermediates for the production of not only 2-thiopheneacetic acids but also thioprofenic acid which is known as an anti-inflammatory agent.

Process for preparing thiophene derivatives

An .alpha.-(2-thienyl)propionic acid can easily be prepared in a high yield and high selectivity by reacting a 2-(dihaloacetyl)thiophene which is easily obtainable by acetylation and halogenation of a substituted or unsubstutitued thiophene, with a methylmetal compound and then reacting an alkali metal hydroxide with the reaction product. .alpha.-(2-Thienyl)propionic acids are useful compounds from which, for example, thioprofenic acid can easily be prepared. Thioprofenic acid is known as an anti-inflammatory agent. As reaction intermediates, 1-(2-thienyl)-1-dihalomethylethanols can be obtained. Which are novel and useful compounds.

Process for the preparation of thiophene derivatives and thiophene

Growing community of inventors

Tokyo, Japan

Kunikazu Sakai