Kyowa Hakko Kogyo Co., Ltd.

Kyowa Hakko Kogyo Kabushiki Kaisha

Abbott Laboratories Corporation

Kitasato Kenkyusho

Kyowa Hakko Kogyo Kabushiki

Kunikatsu Shirahata

Masaji Kasai

Takao Iida

Takashi Nara

Shinzo Ishii

Makoto Morimoto

Ryo Okachi

Motomichi Kono

Hiroshi Kase

Tadashi Ashizawa

Fusao Tomita

Keiichi Takahashi

Yutaka Saito

Shinji Tomioka

Isao Kawamoto

Tatsuya Tamaoki

Katsuichi Shuto

Yuzuru Matsuda

Masahiro Sugimoto

Kazuyuki Mineura

Isao Matsubara

Itaru Takahashi

Nobuo Nakamura

Shuji Okubo

Satoshi Omura

Hirofumi Nakano

Kazuo Yamaguchi

Koji Yamada

Yasuki Mori

Haruo Tanaka

Kiyoshi Nakayama

Seigo Takasawa

Tomoyasu Sato

Kozo Asano

Noriaki Hirayama

Hideo Matsushima

Hiroshi Kawauchi

Seiji Sato

Hiroshi Sano

Akira Karasawa

Susumu Sekine

Moriyuki Sato

Seiga Itoh

Shigeto Kitamura

Tetsuo Oka

Toru Yasuzawa

Akira Sato

Tetsuya Hirano

Shigeo Katsumata

Akiko Saito

Yuko Arai

Kazuhisa Fujimoto

Chikahiro Urakawa

Kinichi Nakano

Tohru Yasuzawa

Kenji Omori

Masayuki Yamato

Isao Maisubara

Yuzuru Matauda

Haruko Tsuchiya

Yuzura Matsuda

Masanori Fukui

Kazuyuki Iwahashi

Toshiro Koguchi

Kazuko Hashizume

Takashi Deguchi

A novel physiologically active substance KS-619-1 having a vasodilative activity is produced by culturing Streptomyces californicus ATCC 3312.

Novel substance KS-619-1, preparation process and pharmaceutical

According to the present invention, a fish growth hormone was isolated from an organ culture broth of the pituitary gland of eels, and further a recombinant DNA incorporated with a DNA coding for the eel growth hormone polypeptide and a microorganism containing the recombinant DNA were obtained. They can be used for mass production of an eel growth hormone.

Eel growth hormone

7-N,8-N-Ethylenemitomycin 8-imines represented by the formula ##STR1## wherein one of the R.sub.1 and R.sub.2 represents carbamoyloxymethyl and another represents hydrogen or both are combined together to form methylene; R.sub.3, R.sub.4, R.sub.5 and R.sub.6 each independently represent hydrogen or C.sub.1-4 alkyl, or R.sub.3 and R.sub.4 may be combined together to represent --(CH.sub.2).sub.n --, wherein n is 3 or 4; and Y and Z represent hydrogen or methyl, provided that when R.sub.1 represents carbamoyloxymethyl and Y represents methyl, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6 and Z are not hydrogen simultaneously, has an excellent antitumor activity.

7-N,8-N-Ethylenemitomycin 8-imines

Mitomycin derivatives of the formula: ##STR1## wherein X is ##STR2## [wherein R.sub.3 is alkyl, cycloalkyl or optionally substituted phenyl; and R.sub.4 is alkyl or cycloalkyl]; n is an integer of 2 to 8; one of R.sub.1 and R.sub.2 is a hydrogen atom and the other is a carbamoyloxymethyl group, or alternatively R.sub.1 and R.sub.2 may be combined together to form a methylene group (.dbd.CH.sub.2); and Y and Z independently represent hydrogen or methyl; exhibit anti-bacterial and anti-tumor activities.

Mitomycin derivatives having anti-tumor and antibacterial utility

Mitomycin derivatives represented by the formula (I): ##STR1## wherein R.sub.1 and R.sub.2 may be the same or different, and represent a hydrogen atom or a lower alkyl group; R.sub.3 and R.sub.4 mean that when R.sub.3 is a hydrogen atom, R.sub.4 represents --CH.sub.2 OCONH.sub.2 or ##STR2## (wherein R.sub.1 and R.sub.2 have the same significances as defined above), or R.sub.3 and R.sub.4 are combined to form .dbd.CH.sub.2 ; Y and Z may be the same or different, and represent a hydrogen atom or a methyl group;   represents .alpha.- or .beta.-bond, provided that Y represents a hydrogen atom when R.sub.4 takes .beta.-configuration, have an excellent anti-tumor activity.

7-n-aminomethylenemitomycin derivative

Disclosure is optically active 1-amino-2-(hydroxyphenyl) ethylphosphonic acid and derivatives thereof which are useful as intermediates for the preparation of phosphorus-containing oligopeptides exhibiting hypotensive activity.

Optially active 1-amino-2-(4-hydroxyphenyl)ethylphosphonic acid and

A new substance K-259-2 having a molecular formula of C.sub.21 H.sub.18 O.sub.7, a molecular weight of 382 and an elemental analysis (%) of H: 4.50, C: 65.53 and N: 0. This substance is of interest in providing a new vasodilating agent in view of its ability to dilate the blood vessel, particularly the artery, of mammals. This substance may be obtained by fermentation of a microorganism Micromonospora sp. K-259 (FERM BP 569).

Substance K-259-2 and a process for producing the same

The present invention provides new mitomycin derivatives of general formula (I) ##STR1## [wherein Y and Z, which may be the same or different, each represents a hydrogen atom or a methyl group;

New mitomycin derivatives, preparation thereof and pharmaceutical

Disclosed is a novel physiologically active substance, K-26, a process for preparation thereof and a pharmaceutical composition containing the same. The composition of matter, K-26, is useful as a hypotensive agent.

Novel physiologically active substances K-26, a process for preparation

A fish growth hormone provided by a purified extract obtained from the pituitary gland of a fish belonging to salmonoid; the hormone is a polypeptide having the following physicochemical properties:

Fish growth hormone

New antibiotic compounds, Fortimicin factors KG.sub.1, KG.sub.2 and KG.sub.3 are produced by fermentation of microorganisms belonging to the genus Micromonospora. The antibiotic compounds are accumulated in the culture liquor and are isolated therefrom.

Fortimicin factor KG.sub.3

A preventive and healing composition for diseases due to lipoxygenase metabolic products, which comprises an effective amount of a compound represented by the formula: ##STR1## wherein R is an alkyl group having 1 to 15 carbon atoms and at least one pharmaceutically acceptable carrier.

Preventive and healing composition for diseases due to lipoxygenase

A substance designated by us as AX-2 and represented by the formula: ##STR1## This substance is produced by culturing a microorganism of the genus Streptomyces and capable of producing AX-2 in a medium to accumulate AX-2 in the cultured broth and isolating AX-2 therefrom. An anti-tumor composition comprising an effective amount of AX-2 in association with a physiologically acceptable carrier or excipient, which is active against Sarcoma 180.

Substance AX-2, a process for producing the same and an antitumor

A novel physiologically active substance K-252 having an antiallergic action is produced by culturing a microorganism of the genus Nocardiopsis.

Physiologically active substance K-252, process for producing same and

Disclosed is a novel physiologically active substance K-4 which has a hypotensive activity, a process production thereof and a pharmaceutical composition containing the same.

Novel physiologically active substance K-4, a process for preparation

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Machida, Japan

Kunikatsu Shirahata