Toray Industries, Inc.

Kunihisa Nagino

Hitoshi Nobumasa

Fumio Nakamura

Gentaro Ohbayashi

Kusato Hirota

Takeshi Arai

Hiromichi Sasamoto

Takao Amioka

Toshihisa Nonaka

Yuji Watanabe

Futoshi Okuyama

Shigeru Suzue

Yuki Takii

Tomoya Yamashiki

Hideo Nakakuki

Syunpei Yoshikawa

Kumie Ozaki

Gentaro Ohbay Ashi

A detecting method includes irradiating a substrate having a concave and convex shape, with laser light collected by a lens; and detecting a height difference of the concave and convex shape by acquiring light intensity of reflected light and/or scattered light from the substrate as image data, and a light irradiation surface of the substrate is arranged at a position closer to the lens than a focal position of the lens is, reflected light and/or scattered light from the light irradiation surface is received as detected light, and a height difference of the substrate is detected based on a change in intensity of the received light.

Detecting method, microarray analyzing method, and fluorescence reading device

A microarray analysis method, in which a microarray obtained by arranging probes on a substrate surface having an irregular shape is irradiated with excitation light and fluorescence amounts of the probes excited by the excitation light are obtained as numerical data, includes a step (a) of measuring the fluorescence amounts of the probes to acquire fluorescence image data, a step (b) of receiving reflected light and/or scattered light from the substrate surface to acquire the irregular shape of the substrate surface of the microarray as alignment image data based on the light receiving intensities of the light, and a step (c) of determining positions of the probes on the fluorescence image data based on the alignment image data.

Microarray analysis method and microarray reading device

A determination method for determining reliability of a selective binding amount of a substance to be examined obtained as detection intensity of a label when a labeled substance to be examined binds to a selective binding substance fixed as a spot on a carrier includes: determining a position of the spot in image data obtained by imaging the detection intensity in the carrier and extracting a pixel group corresponding to the spot; calculating a ratio or a difference between a median value of the detection intensity of the pixel group extracted at the determining and a median value of the detection intensity of the pixel group excluding a certain top proportion of and/or a certain bottom proportion of pixels; and determining quality of the reliability based on the ratio or the difference calculated at the calculating and a certain reference value.

Determination method, determination device, determination system, and computer program

A support carrying an immobilized selective binding substance, that the support surface has a polymer containing the structural unit represented by the following General Formula (1) in an amount of 10% or more with respect all monomer units, and a selective binding substance is immobilized on the support surface by binding to the carboxyl group formed thereon via a covalent bond: (in General Formula (1), R, R, and Reach represent an alkyl or aryl group or a hydrogen atom.)

Support carrying an immobilized selective binding substance

The method of stirring a solution according to the present invention is a method of stirring a solution comprising contacting a selective binding substance immobilized on the surface of a carrier with a solution containing an analyte substance reactive with the selective binding substance, and mixing the fine particles or air bubbles into the solution containing an analyte substance, and moving the fine particles or air bubbles without allowing contact thereof with the selective binding substance-immobilized surface. The present invention provides a stirring method that accelerates the reaction of a carrier-immobilized selective binding substance with an analyte substance and detects a trace amount of analyte at high signal intensity and high S/N ratio. The present invention enables diagnosis and examination in the clinical setting by using a selective binding substance-immobilized carrier such as DNA chip.

Method of agitating solution

Support having selectively bonding substance fixed thereto

A rewritable phase change type optical recording medium having excellent in storage durability such as archival property and overwrite shelf property and is less likely to have increased jitters, lower contrast and bursting due to deterioration by repeated overwriting is disclosed. The optical recording medium comprises a first dielectric layer, a first boundary layer and a recording layer, in tis order, wherein the first boundary layer is in contact with the recording layer. The information in the optical recording medium can be recorded, erased and reproduced by irradiating the recording layer with light. The recording and erasure of information are affected by reversible phase change between amorphous phase and crystalline phase of the recording layer. The first boundary layer comprises a material comprising an oxide, a carbide, a nitride of one or more elements (excluding carbon) belonging to a group 3A through group 6B of the 2 period through the 6 period in the periodic table; carbon; or a compound with carbon and oxygen and/or nitrogen.

Optical recording medium

Phase-change type rewritable optical recording media, such as optical discs, optical cards, and optical tapes, where recorded data can be erased or overwritten and where data can be recorded with high speed and high density by applying a light beam can include an optical recording medium is one that includes a laminate member, which in various embodiments contains a transparent substrate, a first dielectric layer, a recording layer, a second dielectric layer, a light absorbing layer, and/or a reflecting layer. In various embodiments of the invention, the shortest distance between recorded marks in the recording direction along the track is less than &lgr;/NA, with &lgr; and NA denoting the wavelength of the light used and the numerical aperture of the objective lens of the optical head, respectively.

An optical recording medium has a high hardness layer, first dielectric layer, recording layer, second dielectric layer and reflective layer. The hardness of the high hardness layer is larger than the hardness of the first dielectric layer, and the thickness of the second dielectric layer is in the range of 3 to 50 nm. Such a rewritable phase change type optical recording medium may show reduced degradation in the write-start portion and write-end portion of frequently rewritten sectors, and have good jitter characteristics.

An optical recording medium having each of a land and a groove and comprises at least a recording layer, dielectric layers and reflection layer. Recording and erasing of data can be carried out on both land and groove by a phase change between amorphous and crystalline states. The mirror portion may have reflectance characteristics selected from at least one of a reflectance of more than 15% and no more than 35%, when in a crystalline state, and 10% or less, when in an amorphous state. Alternatively, additionally, the depth of the groove may be such as to form an optical path length equal to 1/7 to 1/5 of the wavelength of the reproducing light and the photo-absorbance of the recording layer in the amorphous phase and the photo-absorbance in the crystalline phase may satisfy the following formula, Aa-Ac.ltoreq.10 where Aa is the photo-absorbance (%) of the recording layer in the amorphous phase and Ac is the photo-absorbance (%) of the recording layer in the crystalline phase. In an optical recording method, an edge type recording system is provided on an optical recording medium in which recording and erasing are effected by a phase change between amorphous and crystalline states. Recorded marks are provided by pulse trains each comprising a number of recording power pulses and, additionally, a power pulse, after the last of the recording power pulses, of a power less than a erase power and of a duration in a range of 1.1 to 6 times the duration of the last recording power pulse.

Method for recording on optical recording media

An optical recording medium having each of a land and a groove and comprises at least a recording layer, dielectric layers and reflection layer. Recording and erasing of data can be carried out on both land and groove by a phase change between amorphous and crystalline states. The mirror portion may have reflectance characteristics selected from at least one of a reflectance of more than 15% and no more than 35%, when in a crystalline state, and 10% or less, when in an amorphous state. Alternatively, additionally, the depth of the groove may be such as form an optical path length equal to 1/7 to 1/5 of the wavelength of the reproducing light and the photo-absorbance of the recording layer in the amorphous phase and the photo-absorbance in the crystalline phase may satisfy the following formula,

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Kamakura, Japan

Kunihisa Nagino