Nihon Nohyaku Co., Ltd.

Kunihiro Yabutani

Hitoshi Kurono

Hisanori Matsui

Hiroshi Tanaka

Kuniaki Taninaka

Kenichi Ikeda

Kazuhiro Takagi

Tatsuo Harada

Mitsuru Kajioka

Moriharu Yamamoto

Tsumoru Kodaira

Shigenori Hatta

Keiji Sutoh

A process for producing 1,2,4-triazolin-5-one derivatives represented by the general formula (I) ##STR1## wherein R is a haloalkyl group of 1 to 5 carbon atoms and R.sup.1 is a hydrogen atom, an alkyl group of 1 to 6 carbon atoms, an alkyl group of 1 to 6 carbon atoms having halogen atom substituents, a cycloalkyl group of 3 to 6 carbon atoms, a cycloalkyl group of 3 to 6 carbon atoms having halogen atom substituents, a cyanoalkyl group of 2 to 4 carbon atoms, an alkenyl group of w to 6 carbon atoms, an alkynyl group of 2 to 6 carbon atoms, a lower alkoxyalkyl group of 2 to 6 carbon atoms, a lower alkylthioalkyl group of 2 to 8 carbon atoms, a lower alkylsufinylalkyl group of 2 to 6 carbon atoms, a lower alkylsufonylalkyl group of 2 to 6 carbon atoms, a lower alkoxyalkoxyalkyl group of 3 to 8 carbon atoms, a hydroxycarbonylalkyl group of 2 to 3 carbon atoms, a lower alkoxycarbonylalkyl group of 3 to 6 carbon atoms, a benzylgroup, a benzyl group having 1 to 2 substituents (selected from a halogen atom, a lower alkyl group of 1 to 3 carbon atoms, a lower alkoxy group of 1 to 3 carbon atoms, a nitro group, a lower alkoxycarbonyl group of 2 to 4 carbon atoms, a hydroxycarbonyl group and a phenoxy group), an alpha-methylbenzyl group or a phenethyl group.

Process for producing 1,2,4-triazolin-5-one derivatives, and

A 1,3-dithiol-2-ylidene malonic acid dialkyl ester chich was known as useful agricultural or horticultural fungicide and also as therapeutic agent for treating hepatic diseases can be prepared by a new process which comprises reacting a dialkyloxycarbonylketene dimercaptide with a 1,1-dihalogenoethylene.

Process for producing 1,3-dithiol-2-ylidene malonic acid dialkyl esters

A 1,3-dithiol-2-ylidene malonic acid dialkyl ester which was known as useful agricultural or horticultural fungicide and also as therapeutic agent for treating hepatic diseases can be prepared by a new process which comprises reacting a dialkyloxycarbonylketene dimercaptide with a trihalogenoethane in the presence of a base.

Process for producing 1,3-dithiol-2-ylidene malonates

.alpha.,.alpha.,.alpha.-trifluoro-o-toluic fluoride is produced in good yield and high purity by reacting anhydrous hydrogen fluoride with 1,1,3,3-tetrachloro-1,3-dihydroisobenzofuran or a mixture of .alpha.,.alpha.,.alpha.-trichloro-o-toluic chloride therewith, the mixture being preferably produced by sufficiently photochlorinating o-toluic chloride in mild conditions.

Process for producing .alpha., .alpha., .alpha.-trifluoro-o-toluic

O-Trifluoromethylbenzoic m'-isopropoxyanilide formed by the reaction between o-trifluoromethylbenzoic acid and m-isopropoxyaniline is very effective in controlling agricultural and horticultural plant diseases.

Growing community of inventors

Neyagawa, Japan

Kunihiro Yabutani