Riken Corporation

Toyota Jidosha Kabushiki Kaisha

The University of Tokyo

Kabushiki Kaisha Toyota Chuo Kenkyusho

Chiome Bioscience Inc.

Other

Japan Science and Technology Agency

Smk Corporation

Kawasumi Laboratories. Inc.

Meiji University

Kunihiro Ohta

Takehiko Shibata

Hidetaka Seo

Nobuhiko Muramoto

Norihiro Mitsukawa

Hiroki Sugimoto

Chikara Ohto

Satoshi Kondo

Takahiro Nakamura

Hiroyuki Osada

Hidenori Tanaka

Dai Yamanouchi

Koki Goto

Hajime Takata

Shuichi Ohsato

Shuichi Osato

Yoshio Hirabayashi

Hiroyuki Kamiguchi

Akiho Nakamura

Katsumi Sakai

Kouji Hirota

Kazuto Kugou

Hiroki Ishida

Kaori Honda

Akiho Murayama

A foreign substance removing device includes a tubular member and a retriever configured to be expandable to and contractible from a predetermined shape. The retriever includes main wires disposed to be centered around a tube axis of the tubular member, and sub wires each connecting adjacent ones of the main wires to each other. Each of the main wires is configured to curve when the retriever is expanded such that a space having a predetermined size is provided by the main wires. Each of the sub wires is configured to be foldable at at least one point between the adjacent ones of the main wires. When the retriever is expanded, the folding points of the sub wires are positioned inside the space such that the sub wires do not protrude out of the main wires.

Foreign substance removing device and foreign substance collecting system

A method of modifying the genome of an organism, wherein the modification method includes modifying the genome of the organism by using in a cell of the organism a protein having an optimal temperature for double-stranded DNA breakage activity in an ordinary temperature region.

Method of modifying genome of organism and use thereof

A method of increasing the biomass of a plant that includes planting a plant having plant cells carrying an exogenous gene that encodes a thermophilic restriction enzyme that promotes double-stranded DNA breakage, and growing the plant at least until after true leaf development, wherein the mean biomass of plants having the plant cells carrying the exogenous gene that are grown at least until after true leaf development is increased in comparison with the mean biomass of plants of the same species that do not carry the exogenous gene that are grown for the same amount of time.

Method for increasing plant biomass using an exogenous gene encoding a thermophilic restriction enzyme

The present invention provides a method for obtaining diverse novel genes by inducing somatic cell homologous recombination at genetic loci in somatic cells. By controlling transcription activity of a gene that exists at a genetic locus in a eukaryotic organism cell wherein DNA homologous recombination is occurring at an arbitrary genetic locus, somatic cell homologous recombination is induced between said gene and a gene having a DNA sequence similar to said gene that exists in a region upstream of a transcription promoter, whereby it is possible to obtain diverse novel genes having a plurality of genetic information.

Method of inducing homologous recombination of somatic cell

It is an object of the present invention to provide a method for stably and efficiently binding a compound to magnetic beads. The present invention relates to a method for producing compound-bound magnetic beads, which comprises: allowing a compound to come into contact with magnetic beads, on the surface of each of which a photoreactive compound has bound; extending the magnetic beads together with the compound on a support; and applying light to the magnetic beads to form a covalent bond between the photoreactive compound and the compound.

Method to prepare magnetic beads conjugated with small compounds

According to the present invention, a technique of increasing the frequency of genetic recombination in genomic DNA of a plant is established. Such technique comprises: introducing a restriction enzyme gene that can be expressed in a target plant cell into the plant cell and causing the restriction enzyme gene to be transiently expressed so as to induce genetic recombination of genomic DNA; or introducing a promoter and a restriction enzyme gene using themethod so as to induce genetic recombination of genomic DNA.

Mutant plant, a method for producing thereof and a method of increasing frequency of a genetic recombination

In order to identify a factor demonstrating a repellent effect on axon extension of a neuron, lysophosphatidylglucoside (LPG) has been found to have an activity as a chemorepellent effect on axon guidance of a DRG sensory neuron specific to a neuron expressing TrkA, an NGF receptor. In addition, it has been found out that suppressing the function of LPG makes it possible to suppress a repellent effect of LPG on axon extension of a neuron expressing TrkA. A molecule capable of suppressing the function of LPG can be a composition promoting repairing of a neural circuit in neuronal damages and the like.

Antibody binding to lysophosphatidylglucoside, and composition comprising the same

The present invention provides a novel method for obtaining diverse antibodies as a result of markedly enhancing the somatic homologous recombination at an antibody locus in immunocytes. By putting immunocytes in which DNA homologous recombination is occurring at an antibody locus (for example, DT40 cells and the like) into contact and the like with histone acetylase inhibitor and the like (for example, trichostatin A and the like), thereby relaxing the chromatin structure at said antibody locus, somatic homologous recombination at an antibody locus is enhanced, and the production of diverse antibody molecules is made possible. The production of antibodies that bind specifically to antigens from cell populations in which the antibody molecules have been diversified by the enhancement of somatic homologous recombination is made possible by using an appropriate selection method (for example, beads coated with antigen and the like).

Method of enhancing homologous recombination of somatic cells and method of constructing specific antibody

A power line communication system which enables high quality communication utilizing a pair of power lines connected to a vehicle mounted battery, has a pair of communication lines connected to a pair of power lines, respectively, to communicate a high frequency signal of 1 MHz or more. This system has a balance filter which is interposed between each of the communication lines and a vehicle mounted communication apparatus, the filter, a circuit configuration of which is formed in balance type. The communication system also has a pair of electrically balanced lines which are connected between the balance filter and each of the communication apparatuses and are power-fed from the battery, for performing communication between the communication apparatuses.

Power line communication system

The present invention relates to a method for increasing genetic recombination frequency in a genomic DNA and a method for inducing genome rearrangement. Specifically, according to the present invention there are provided: the method for increasing genetic recombination frequency in a cell in which genetic recombination takes place at any sites in the genome, comprising causing a restriction enzyme to be expressed in the cell, inducing transient activation of the restriction enzyme, and then introducing 2 or more double strand cleavages into any genomic DNA of the cell, so as to increase the genetic recombination frequency; the method for inducing genome rearrangement through the use of the above method; and cells each prepared through the use of the above 2 methods.

Method of inducing genome reorganization via intracellular activation of thermostable multifrequency DNA-cleaving enzyme

Growing community of inventors

Tokyo, Japan

Kunihiro Ohta