Mitsubishi Chemical Industries Limited

Mitsubishi Kasei Corporation

Mitsubishi Chemical Corporation

Kunihiro Ninomiya

Akihiro Tobe

Ryoji Kikumoto

Harukazu Fukami

Issei Nitta

Mamoru Sugano

Hiroto Hara

Mitsuo Egawa

Shuji Morita

Ken-Ichi Saito

Shinichiro Fujimori

Satoshi Yamazaki

Makoto Kawamura

Ryozo Yamaguchi

Tadashi Oohama

Haruo Imai

Kyoji Kikumoto

There are disclosed a 9-acylamino-tetrahydroacridine derivative represented by the following formula (I): ##STR1## wherein R ##STR2## are as defined in the specification, its optical antipode or pharmaceutically acceptable acid addition salt thereof and a memory enhancing agent containing the same as an active ingredient.

9-acylamino-tetrahydroacridine derivatives and memory enhancing agent

Ethanone oximes represented by the following general formula: ##STR1## wherein R.sup.1 represents a cycloalkyl group, aryl group, aralkyl group, aryloxy group, aralkyloxy group, arylthio group or aryl sulfonyl group, those groups being optionally substituted with a substituent selected from an alkyl group having 1 to 3 carbon atoms, an alkoxy group having 1 to 3 carbon atoms and a halogen atom, piperidino group, piperazino group, 4-alkyl substituted piperazino group, imidazolyl group 4-alkyl substituted imidazolyl group or substituted amino group,

Ethanone oximes and pharmaceutical compositions thereof

Ethanone oximes represented by the following general formula: ##STR1## wherein R.sup.1 represents a cycloalkyl group, aryl group, aralkyl group, aryloxy group, aralkyloxy group, arylthio group or aryl sulfonyl group, those groups being optionally substituted with a substituent selected from an alkyl group having 1 to 3 carbon atoms, an alkoxy group having 1 to 3 carbon atoms and a halogen atom, piperidino group, piperazino group, 4-alkyl substituted piparazino group, imidazolyl group, 4-alkyl substituted imidazolyl group or substituted amino group,

A novel 4-piperidinecarboxamide derivatives represented by the general formula (I): ##STR1## wherein each R.sup.1 and R.sup.2 represents a hydrogen atom, or R.sup.1 together with R.sup.2 represents a cyclopentanespiro or cyclohexanespiro group; R.sup.3 represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, an aralkyl group or an indolylalkyl group; and n is an integer of 1 or 2; is disclosed herein. The novel compound is useful as the agent for improving the impaired brain fuction.

4-piperidinecarboxamide derivatives

Novel 4-aminopyridine derivatives represented by the general formula (I): ##STR1## wherein A and B independently represent ##STR2## and n is an integer of 1 or 2; as well as their pharmaceutically acceptable acid addition salts are disclosed herein. The novel compounds are useful as the agent for improving impaired brain function.

4-aminopyridine derivatives for improving impaired brain function

This invention relates novel thieno[2,3-d]pyrimidine derivatives represented by the following general formula (I): ##STR1## or salts thereof; wherein R.sup.1 and R.sup.2 independently represent hydrogen, halogen or alkyl group having 1 to 6 carbon atoms; or R.sup.1 and R.sup.2 may concatenate to form a cycloalkylene group having 5 or 6 ring carbon atoms; R.sup.3 and R.sup.4 independently represent hydrogen or alkyl group having 1 to 6 carbon atoms; R.sup.5 represents a member selected from

Thieno[2,3-d]pyrimidine derivatives and salts thereof

(3-Aminopropoxy)bibenzyl derivatives are prepared and found useful as pharmaceutical agents, particularly as inhibitors of platelet aggregation.

Pharmaceutically active (3-cyclic aminopropoxy)bibenzyls as inhibitors

Pharmaceutically active (3-aminopropoxy)bibenzyl derivatives

(Omega-aminoalkoxy)bibenzyls are prepared and found useful as pharmaceutical agents, particularly as inhibitors of platelet aggregation.

Pharmaceutically active (omega-aminoalkoxy)bibenzyls

2-(4-aminobutoxy)stilbenes are prepared and found useful as pharmaceutical agents, particularly as anticonvulsants and skeletal muscle relaxants.

Pharmaceutically active 2-(4-aminobutoxy)stilbenes

19-Norethisterone or 19-norandrost-4-ene-3,17-dione is purified by passing its solution in an aromatic hydrocarbon, an alkyl halide or an ester of acetic acid through a column packed with basic alumina and then crystallizing it.

Growing community of inventors

Machida, Japan

Kunihiro Ninomiya