Otsuka Pharmaceutical Company, Limited

Kunihiko Tatsumi

Satoshi Yamada

Keisuke Miyajima

Takeshi Yamauchi

Hiroshi Kiyokawa

Kunihiko Kiyono

Kazumasa Kishi

Koji Edamatsu

Kinji Hashimoto

Makoto Inoue

Masatoshi Inai

Yoshifumi Chone

Kazunobu Kurisu

This invention provides a condensed pyrazole derivative of the Formula (1): ##STR1## (where A denotes CH or N, R.sup.0 and R.sup.3 denote same or different, a hydrogen atom or a lower alkyl group, R.sup.1 and R.sup.2 denote same or different, a hydrogen atom, a lower alkyl group, a lower alkoxy group, a lower alkylthio group, a nitro group or a halogen atom, m denotes 1 or 2, and n denotes 1, 2 or 3, provided that, when n is 2, two R.sup.2 may be connected to each other to form a lower alkylenedioxy group), or its pharmaceutically acceptable salt. This derivative or its salt is excellent in the effect of inhibiting the expression of action of androgen, thereby being excellent in therapeutical effect of benign prostatic hypertrophy, prostatic carcinoma, etc., and has a long lasting of efficacy and high oral absorption.

Condensed pyrazole derivatives, and androgen inhibitor

Pyrimidine derivatives, method of manufacturing the same, and androgen

Condensed pyrazole derivatives, method of manufacturing the same, and

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Otsu, Japan

Kunihiko Tatsumi