Kanto Kagaku Kabushiki Kaisha

Nagoya Industrial Science Research Institute

Other

Hokkaido University

Kunihiko Murata

Masahito Watanabe

Takao Ikariya

Junichi Hori

Takeaki Katayama

Kunihiko Tsutsumi

Ryoji Noyori

Takeshi Ohkuma

Noriyuki Utsumi

Toshihide Takemoto

Masahiro Yoshida

Masami Kozawa

Hideyuki Ikehira

Noriyoshi Arai

Nobuhito Kurono

Taito Hatakeyama

Kouichi Tanaka

Takeshi Okuma

Takeshi Ota

Toru Yokozawa

Eiji Katayama

Takashi Miki

The purpose of the invention is to provide a novel organometallic compound that can be utilized as a catalyst having high generality, high activity, and excellent functional group selectivity. The invention pertains to a novel organometallic compound represented by general formula (1) that catalyzes a reductive amination reaction.

Method for producing novel organometallic complex and amine compound

[Problem] The present invention aims to provide a novel organometallic compound that can be used as a general-use highly active catalyst with superior selectivity for functional groups. [Means for Solving Problem] The present invention relates to an organometallic compound having a novel specific structure of general formula (1): and to a general-use highly active catalyst used in reductive amination reaction with superior selectivity for functional groups that comprises said organometallic compound, and to a process for preparing amine compounds by reductive amination reaction using said catalyst.

Organic metal complex and process for preparing amine compound

Methods are provided for producing an optically active secondary alcohol at a high optical purity by hydrogenating a substrate carbonyl compound at a high efficiency using as a catalyst a ruthenium complex bearing as a ligand certain optically active diphosphine compound and a readily synthesized amine compound. For example, aromatic ketones and heteroaromatic ketones are reacted with hydrogen and/or a hydrogen donating compound in the presence of the ruthenium complex.

Process for producing optically active secondary alcohol

The object of the present invention is to solve the problems in the prior arts, and to find more improved reaction conditions for suppressing the racemization of the product and obtaining an optically active alcohol at a high optical purity. The inventors achieved to solve the above problems by using a solvent system that is capable of resolving both an asymmetric catalyst and a formate salt, allowing the hydrogen source and the asymmetric catalyst to be present in the same phase.

Process for producing optically active alcohol

The problem to be resolved by the present invention is to provide a method for efficiently synthesizing optically active lower aliphatic alcohols that have difficulty in separation from organic solvents, without using a special reactor. The present invention relates to a method for producing an optically active aliphatic alcohol having a fluorine atom at &#x3b1; position, wherein an optically active alcohol is produced by reacting an aliphatic ketone having a fluorine atom at &#x3b1; position in water using a formate, under the presence of an asymmetric catalyst represented by general formula (1) and an acid.

Process for producing optically active aliphatic fluoroalcohol

A novel ruthenium complex which is a highly efficient catalyst useful for the production of optically active 3-quinuclidinols, and a process for production of optically active 3-quinuclidinols using the ruthenium complex as a catalyst, where the optically active 3-quinuclidinols are useful as an optically active, physiologically active compound utilized in medicines and agrichemicals or as a synthetic intermediate such as a liquid crystal material.

Process for production of optically active quinuclidinols

The invention provides a method for producing optically active 3-quinuclidinols having one or more substituted groups at the 2-position; wherein 3-quinuclidinones having one or more substituted groups at the 2-position are reacted with compounds providing hydrogen in the presence of a certain metal complex.

Method for producing optically active quinuclidinols having one or more substituted groups at the 2-position

A hydrogenation promoter of the present invention is produced by reacting an alkyne compound or an alkene compound, a palladium compound represented by a general formula Pd(II)XL(where L represents a monodentate ligand or a polydendate ligand other than a phosphorus-containing ligand (when two or more Ls are present in the compound, the Ls may be the same or different), X represents an anionic group, j represents a value determined according to the valence of X so that Xhas a valence of &#x2212;2 as a whole, and k represents an integer in the range of 0 to 4), and a base in an organic solvent. Specifically, The hydrogenation promoter of the invention includes palladium nanoparticles containing the alkyne compound or the alkene compound as an agglomeration-preventing agent.

Hydrogenation promoter, hydrogenation catalyst, and process for producing alkene compound

A sulfonate catalyst represented by the formula below and a ketone compound are placed in a solvent, and the ketone compound is hydrogenated by mixing in the presence of hydrogen to produce an optically active alcohol. 

Sulfonate catalyst and method of producing alcohol compound using the same

A process for preparing optically active nitro compounds and cyano compounds using a metal complex, which is obtained by reaction of an optically active nitrogen-containing compound and a periodic table group VIII metal complex, in the asymmetric Michael reaction.

Process for preparing optically active nitro compounds and cyano compounds

A highly efficient process is provided for producing an optically active compound having high optical purity by an asymmetric reaction using as a catalyst a transition metal complex having an optically active nitrogen-containing compound as an asymmetric ligand.

Process for producing optically active compound

Ruthenium complexes and process for preparing alcoholic compounds using these

A process for producing an optically active amino alcohol is provided that includes a step in which a nitro ketone or a cyano ketone is reacted with a hydrogen-donating organic or inorganic compound in the presence of a transition metal compound catalyst having an optically active nitrogen-containing compound as an asymmetric ligand to give an optically active nitro alcohol or an optically active cyano alcohol, and a step in which the above optically active alcohol is further reduced to efficiently produce an optically active amino alcohol.

Process for producing optically active amino alcohols and intermediates therefore

Alcohols are produced in a practical and advantageous method, by the hydrogenation of a carbonyl compound under mild conditions, by reacting the carbonyl compounds with hydrogen in the presence of a bipyridyl derivative, a group VIII transition metal complex, and a base, or by reducing a carbonyl compound in the presence of a bipyridyl derivative, a group VIII transition metal complex, a base, and an alcoholic solvent.

Growing community of inventors

Soka, Japan

Kunihiko Murata