Ebara Corporation

Daiichi Sankyo Company, Limited

Kunihiko Fujii

Makoto Kobayashi

Masakazu Yamamoto

Makoto Mori

Yoshio Miyake

Koji Isemoto

Kikuichi Mori

Hiromi Sakacho

Seigo Katsuta

Masayoshi Moriya

Takayuki Baba

Atsushi Aoyagi

Masaharu Inui

Tsuyoshi Shinozuka

Tomoharu Tsukada

Yukari Onishi

The present invention relates to a novel pyridine derivative or a pharmacologically acceptable ester thereof, or a pharmacologically acceptable salt of the derivative or ester, which has an excellent hypoglycemic effect or treats and/or prevents the onset of a disorder of carbohydrate or lipid metabolism or a disease mediated by peroxisome proliferator-activated receptor (PPAR) &#x3b3;. A compound represented by the general formula (I): [wherein R represents a pyridyl group substituted with 1 to 3 group(s) independently selected from Substituent Group A, and Substituent Group A represents a halogen atom, a C-Calkyl group and a C-Calkoxy group] or a pharmacologically acceptable ester thereof, or a pharmacologically acceptable salt of the compound or ester.

Pyridine derivative

The present invention relates to a compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof having an excellent effect of inhibiting 11&#x3b2;-hydroxysteroid dehydrogenase type 1: General formula (I) wherein Rrepresents a phenyl group that may be substituted with 1 to 5 group(s) independently selected from substituent group A or a heterocyclic group that may be substituted with 1 to 4 group(s) independently selected from substituent group A; Rindependently represents a halogen atom or a C-Calkyl group; n represents an integer of 0 to 2; and substituent group A represents the group consisting of halogen atoms, C-Calkyl groups, and so forth.

Tetrahydrothiazepine derivative

A pump casing made of sheet metal has an outer casing having a suction nozzle, and an inner casing housed in said outer casing and spaced therefrom. A resilient seal is disposed in a gap defined between the outer casing and an inner casing. An impeller is rotatably disposed in the inner casing with a clearance defined between a liner portion of the inner casing and the impeller. The resilient seal is effective to absorb deformations of the outer casing, such deformations of the outer casing are not transmitted to the inner casing.

Pump casing made of sheet metal

Growing community of inventors

Tokyo, Japan

Kunihiko Fujii