Other

Chondrex Inc.

Muromachi Chemical Co., Ltd.

Kuniaki Terato

Hiroshi Shionoya

Sadaichi Iwashita

It is believed that the abnormal absorption of endotoxin present in the gastrointestinal tract relates to the pathogenesis of autoimmune diseases such as rheumatoid arthritis. In an animal model for rheumatoid arthritis, it is observed that arthritis is improved by removing endotoxin. The present invention provides an endotoxin-adsorbent, which is capable of removing endotoxin in the gastrointestinal tract and can be administered to humans safely. By using a non-digestible and non-absorbable, and therefore, safe endotoxin-adsorbent, which has a high endotoxin-binding capacity for removing large amounts of endotoxin present in the gastrointestinal tract, it is possible to prevent and treat autoimmune diseases such as rheumatoid arthritis.

Endotoxin adsorbent for the prevention and treatment of autoimmune diseases

Endotoxin-adsorbent for the prevention and treatment of autoimmune diseases

A water circulation and filtration system for maintaining a high level of water quality in aquariums is provided. In one embodiment, the inventive system comprises a vertical water flushing tube connected to a water supply or a reverse power-head pump and having an opening positioned in proximity to the base of the aquarium. A water circulation tube and water draining tube, each of which has openings located immediately above the base of the aquarium, are provided at the opposing end of the aquarium. The water circulation tube is connected at its other end to a standard filter, while the water draining tube is connected at its other end to a hose leading to a sink, drain or external container. In a second embodiment, water from the aquarium passes through a water draining tube to a filtration chamber which is connected in series to at least one additional filtration chamber. A pump is connected to the final filtration chamber and positioned, in the direction of water flow, after the final filtration chamber. Filtered water passes from the final filtration chamber into the aquarium by means of a water draining tube.

Aquarium cleaning system

A water circulation and filtration system for maintaining a high level of water quality in aquariums is provided. Preferably the system is used in conjunction with a gravel screen, which is located just above the base of the aquarium. The inventive system comprises a vertical water flushing tube connected to a water supply or a reverse power-head pump and having an opening positioned in proximity to the base of the aquarium and below the gravel screen. A water circulation tube and water draining tube, each of which have openings located immediately above the base of the aquarium and below the gravel screen, are provided at the opposing end of the aquarium. The water circulation tube is connected at its other end to a standard filter, while the water draining tube is connected at its other end to a hose leading to a sink, drain or external container.

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Redmonde, WA, United States of America

Kuniaki Terato