Showa Denko Kabushiki Kaisha

Showa Denko K.k.

Kuniaki Shimbo

Keisuke Mano

Hiroshi Suzuki

Nobuyuki Nagato

Shinobu Ito

Eiji Ogata

Ryuji Takahashi

Isamu Taguchi

Toshio Tokuda

Takashi Kotsuka

Hisako Sakuma

A particulate hydrophobic polymer produced by reacting (A) a particulate crosslinked polymer having a hydroxyl group with (B) a crosslinkable epoxy compound, hydrolyzing the epoxy bonds, and then reacting the obtained compound having a hydroxyl group with (C) an epoxy compound having from 6 to 40 carbon atoms in total, a production process therefor, a column for reversed-phase liquid chromatography, and an analysis method using the column. By using the particulate hydrophobic polymer of the present invention having a remarkably high acid/alkali resistance, a sharp chromatogram for polycyclic aromatic compounds is obtainable with the swelling and shrinkage of the particulate polymer itself reduced and without reducing the column efficiency among various solvents even when the eluent in the column is variously exchanged.

Particulate hydrophobic polymer, production process therefor and column for reversed-phase high-performance liquid chromatography

Disclosed are (1) a porous polymer particle comprising a polymer substrate having ester bonds connected to a group containing a quaternary ammonium structure through a spacer molecule, (2) an alkali-resistant, high-strength porous polymer particle having ester bonds connected to a group containing a quaternary ammonium structure through a spacer molecule, a part of the ester bonds being saponified and converted to a hydroxyl group(s), (3) a porous polymer particle comprising a polymer substrate having ester bonds connected to a group containing a quaternary ammonium structure through a spacer molecule, the porous polymer particles being treated with an alkaline solution to generate a hydroxyl and/or a carboxyl group on a surface of the substrate, (4) an anion exchanger comprising any one of the particles (1) to (3) above, (5) a packing material for anion chromatography comprising the anion exchanger (4) above, (6) a column for anion chromatography using the anion exchanger (4) above, and (7) a method for measuring anions using the anion exchanger (4) above.

Porous polymer particle, anion exchanger, producing method thereof, column for ion chromatography, and method for measuring anions

The present invention relates to a packing agent for reversed phase liquid chromatography, including crosslinked polymer base particles which are obtained by aqueous suspension-polymerization of a crosslinkable vinyl ester or vinyl ether having a hydroxyl group within the molecule and which has an exclusion limit molecular weight of 100,000 or less in terms of standard polystyrene by size exclusion chromatography, wherein an acyl group having from 4 to 24 carbon atoms is ester-bonded to a part of hydroxyl groups in the crosslinked polymer base particles. The present invention also provides a production process of a packing agent, a column for reversed phase liquid chromatography using the packing agent, and an analysis method by reversed phase liquid chromatography using the packing agent.

Packing agent for reversed phase liquid chromatography and production process thereof

Porous co-polymer particles, process for preparing the same and use of the same

A preparation for administration to animals, comprising a sparingly soluble L-ascorbic acid-2-phosphoric ester salt having a solubility in water of 10 wt % or less, the solubility being a value obtained by placing 100 g of purified water in a 200 ml-volume beaker, stirring the water while keeping the temperature at 20&deg; C., adding 0.1 g of the L-ascorbic acid-2-phosphoric ester salt every 5 minutes by taking care not to cause gelation, and 30 minutes after the addition of L-ascorbic acid-2-phosphoric ester salt when the undissolved L-ascorbic acid-2-phosphoric ester salt is observed visually in the aqueous solution, determining the amount in weight percentage of L-ascorbic acid-2-phosphoric ester salt added based on water, and a method for feeding animals, using the preparation.

Preparation for administration to animals and feeding method thereof

A process of purifying L-ascorbic acid 2-phosphate is disclosed, comprising passing a solution containing L-ascorbic acid 2-phosphate through a column of a basic anion exchanger resin whose ion-exchange groups consist essentially of a primary amine group, a secondary amine group, a tertiary amine group or a mixture thereof, and eluting the L-ascorbic acid 2-phosphate with an aqueous solution of a mineral acid or an inorganic salt. L-ascorbic acid 2-phosphate can be isolated at a high efficiency through easy steps.

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Kanagawa, Japan

Kuniaki Shimbo