Juridical Foundation the Chemo-sero-therapeutic Research Institute

Kuniaki Sakamoto

Mitsuo Sakoh

Tetsuo Kawahara

Kunio Ohkuma

Shin Sakuma

Hisashi Kitagawa

Saneo Nonaka

Isao Gotoh

Disclosed is a method for the purification of rabic virus, which comprises subjecting a solution containing the rabic virus to column chromatography using, as a gel for chromatography, a sulfuric acid ester of cellulose or a crosslinked polysaccharide. The method can provide highly purified rabic virus which is useful for obtaining an effective vaccine against rabies.

Method for purfication of rabic virus

Disclosed is a method for the purification of Japanese encephalitis virus, which comprises subjecting a solution containing the Japanese encephalitis virus to column chromatography using, as a gel for chromatography, a sulfuric acid ester of cellulose or a crosslinked polysaccharide. The method can provide highly purified Japanese encephalitis virus, which is useful for obtaining an effective vaccine against Japanese encephalitis.

Method for purification of Japanese encephalitis virus

A method for producing highly pure LPF-HA (Leucocytosis-promoting Factor agglutinin) from culture media of Bordetella pertussis in a high yield by an affinity chromatography using a denatured ceruloplasmin as a ligand. The LPF-HA obtained by this invention is highly pure and does not contain almost endotoxin of B. pertussis and is useful for the preparation of various reagents utilizing the physiological activities, a medicine for treating diabetes, and a pertussis vaccine.

Method for the purification of LPF-HA

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Kumamoto, Japan

Kuniaki Sakamoto