Toray Industries, Inc.

Kuniaki Kawamura

Hiroshi Nagase

Takashi Endoh

Toshiaki Tanaka

Koji Kawai

Junzo Kamei

Jun Hayakawa

Jun Utsumi

Naoki Izumimoto

Toshikazu Komagata

Hideaki Inada

Tomohiko Suzuki

Tsutomu Suzuki

Noriyuki Hirano

Takashi Endo

Koji Oshima

Hiroshi Nagabukuro

Kimiyasu Shiraki

Tadatoshi Hashimoto

Morihiro Fujimura

Yoshitaka Yoshizawa

Yasushi Kuraishi

Koji Ohshima

The present invention relates to a therapeutic agent for neuropathic pain containing, as an active ingredient, a compound represented by general formula (I) or a pharmacologically acceptable acid addition salt thereof: (wherein R, R, R, R, R, R, R, R, A, and B have the same definitions as those described in the specification), and an animal model produced by administering (+)-4a-(3-hydroxyphenyl)-2-methyl-1,2,3,4,4a,5,12,12a-octohydro-trans-quinolino[2,3-g]isoquinoline. The present invention makes it possible to perform drug treatment for neuropathic pain. The therapeutic effect of a compound against neuropathic pain can also be evaluated.

Remedies for neuropathic pain and model animals of neuropathic pain

An analgesic which may be applied to wide variety of pain from various causes is disclosed. The analgesic comprises as an effective ingredient a specific morphinan derivative having a nitrogen containing heterocyclic group, such as compound 1: 

Analgesic and methods of treating pain

A therapeutic agent for sepsis and various symptoms accompanying sepsis (such as septic shock, disseminated intravascular coagulation syndrome, adult respiratory distress syndrome and multiple organ dysfunction) is disclosed. The therapeutic agent for sepsis according to the present invention comprises as an effective ingredient an opioid &#x3ba; receptor agonist compound such as (&#x2212;)-17-(cyclopropylmethyl)-3,14&#x3b2;-dihydroxy-4,5&#x3b1;-epoxy-6&#x3b2;[N-methyl-trans-3-(3-furyl)acrylamide] oxide derivative. The opioid &#x3ba; receptor agonist compound may be administered as it is or in the form of a pharmaceutical composition prepared by mixing the compound with a known pharmaceutically acceptable acid, carrier or vehicle orally or parenterally.

Remedies for sepsis

The invention provides a morphinan derivative of the Formula (I): wherein Ris methyl, cyclopropylmethyl or the like; Rand Rare hydroxy, methoxy, acetoxy or the like; both Y and Z are valence bonds, &#x2014;C(&#x2550;O)&#x2014; or the like; X is C-Ccarbon chain (one of the carbon atoms may be substituted by oxygen, sulfur or nitrogen) constituting a part of the ring structure, or the like; (R)k is substituted or non-substituted benzene fused ring, carbonyl group or the like; Ris hydrogen or the like; Rand Rare bound to represent &#x2014;O&#x2014;, or the like, and Ris hydrogen or the like or a pharmaceutically acceptable acid addition salt thereof. The invention also provides a therapeutic or prophylactic agent for urinary frequency or urinary incontinence, comprising as an effective ingredient the morphinan derivative or the pharmaceutically acceptable acid addition salt thereof; a method for therapy or prophylaxis of the diseases.

Remedies or preventives for urinary frequency or urinary incontinence and morphinan derivatives having nitrogen-containing heterocyclic group

Disclosed is an agent for improving learning and/or memory, which is useful for therapy of dementia accompanying disorder of memory due to a cerebrovascular disease, neurodegenerative disease such as Alzheimer's disease, endocrine disease, nutritional or metabolic disorder, infectious disease, drug addiction or the like. The agent for improving learning and/or memory according to the present invention comprises as an effective ingredient an isoquinoline derivative having a specific structure, such as (4aR, 12aR)-2-methyl-4a-(3-hydroxyphenyl)-1,2,3,4,4a,5,12,12a-octahydro-quinoline&lsqb;2,3-g&rsqb;isoquinoline or a pharmaceutically acceptable salt thereof.

Agent for improving learning or memory

Remedies for drug addiction

This invention provides an antipuritic comprising an opiate &kgr; receptor agonist as an effective component, a new morphian quaternary ammonium salt derivative and a new morphian-N-oxide derivative which are useful in treating puritus complicated with some diseases.

Antipruritic

A morphinan derivative or its pharmacologically allowed acid addition salt represented with compound I,

Morphinan derivative and its pharmaceutical applications

This invention provides an antipruritc comprising an opiate &kgr; receptor agonist as an effective component, a new morphinan quaternary ammonium salt derivative and a new morphinan-N-oxide derivative which are useful in treating pruritus complicated with some diseases.

A morphinan derivative or its pharmaceutically acceptable acid addition salt represented with, for example,

Morphinan derivatives and pharmaceutical use thereof

This invention provides an antipruritic comprising an opiate &kgr; receptor agonist as an effective component, a new morphinan quaternary ammonium salt derivative and a new morphinan-N-oxide derivative which are useful in treating pruritus complicated with some diseases.

Growing community of inventors

Kamakura, Japan

Kuniaki Kawamura