Microbio Co. Ltd.

Oneness Biotech Co.

Kung-Ming Lu

Nien-Yi Chen

Yueh-Ju Wang

Tien-Tien Cheng

Min-Liang Kuo

Jen-Wei Chen

Ai-Jen Yang

Ming-Hong Chuang

Cheng Der Tony Yu

A method for preparing a(PA) extract, the method comprising extracting an above-ground part ofwith an extracting solution that comprises a solvent having a suitable polarity index, filtrating and concentration the extract thus produced, and subject the concentrated extract to a chromatographic separation process using a hydrophobic interaction chromatography resin to produce the PA extract.

Methods for preparation ofextracts

Methods for treating a disorder associated with immunoglobulin E (IgE) in a subject with antibodies capable of binding to the Cεmx domain of a membrane-bound IgE. The subject can be administered with at least two doses of the antibody, the two doses being at least three months apart.

Treating IgE-mediated allergic diseases

Combined therapy of cancer using an immune check point modulators (e.g., an immune checkpoint inhibitor) and a fermented product, which may be prepared using symbiotic microbiota.

Combined cancer therapy with immune checkpoint modulators and fermentation products by symbiotic microbiota

Methods for treating a disorder associated with immunoglobulin E (IgE) in a subject with antibodies capable of binding to the C&#x3b5;mx domain of a membrane-bound IgE. The subject can be administered with at least two doses of the antibody, the two doses being at least three months apart.

The present invention relates to a method for activating tumor-infiltrating lymphocytes (TILs) in a subject in need, particularly by administering to the subject a fermented composition generated via fermentation of symbiotic microbiota in a medium.

Method of activating tumor-infiltrating lymphocytes (TILs)

The present invention provides a topical formulation comprising an active agent, which comprises salvigenin and optionally asiaticoside. The present invention also relates to the use of the topical formulation for the promotion of wound healing.

Topical formulation for promoting wound healing

The present invention relates to use of a fermented soy extract as a prebiotic composition to protect beneficial bacteria in the gastrointestinal tract of an animal. Particularly, the fermented soy extract of the invention exhibits the prebiotic activity even under an antibiotic treatment. Also disclosed is combined use of an antibiotic and the fermented soy extract of the invention, which has advantages over administration of the antibiotic alone, such as decreasing the effective dose of the antibiotic and/or reducing side effects resulting from the antibiotic treatment.

Use of a fermented soy extract as a prebiotic composition

The present invention relates to the preparation of therapeutic compositions comprising of fermented soy extracts made with lactic acid bacteria and the optional addition of at least a yeast. The invention also relates to therapeutic uses of such extracts in promoting general health, improving the health of subjects, preventing and/or treating cancer, preventing infections, reducing the incidence of infections, treating infections, treating asthma, treating inflammation, modulating the immune system and treating immune disorders.

Methods for inhibiting cancer growth, reducing infection and promoting general health with a fermented soy extract

This invention relates to a use of a fermented (L.) extract prepared by fermenting an aqueous (L.) extract with at least one lactic acid bacteria together with at least one yeast, in enhancing Natural Killer (NK) cell activity. In particular, the fermented (L.) extract can be used in preventing and/or treating a disease in which NK cell activation is implicated in a subject, such as cancer, infectious diseases and modulating the immune system.

Method of using fermented glycine max (L) extract for enhancing natural killer cell activity

This invention relates to a method of producing fermented extract to obtain composition that has inhibition action on bacteria infection. The fermented extract is prepared by symbiotic culture of yeast and lactic acid bacteria, removing microbial cells from the resultant culture solution and concentrating the prepared culture solution.

Growing community of inventors

Taipei, Taiwan

Kung-Ming Lu