Actavis Group Ptc Ehf

Actavis Group Pct Ehf

Kundan Singh Shekhawat

Nitin Sharadchandra Pradhan

Girish Dixit

Krishnadatt Sharma

Jon Valgeirsson

Disclosed herein is an improved, commercially viable and industrially advantageous process for the preparation of quinoline-3-carboxamide derivatives such as laquinimod, or a pharmaceutically acceptable salt thereof, in high yield and purity.

Process for preparing quinoline-3-carboxamide derivatives

Provided herein is an improved, convenient, commercially viable and environmentally friendly process for the preparation of varenicline or a pharmaceutically acceptable salt thereof comprising reacting 1-(4,5-diamino-10-aza-tricyclo[6.3.1.0]dodeca-2(7),3,5-trien-10-yl)-2,2,2-trifluoro-ethanone with chloroacetaldehyde in the presence of an oxygen source. Provided further herein is an improved and industrially advantageous process for the preparation of 1-(4,5-diamino-10-aza-tricyclo[6.3.1.0]dodeca-2(7),3,5-trien-10-yl)-2,2,2-trifluoro-ethanone.

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Rajasthan, India

Kundan Singh Shekhawat