Northwestern University

Icu Medical Inc.

Hospira, Inc.

Quidel Corporation

Kunal Sur

Timothy Lewis Ruchti

Anatoly S Belkin

David M Kelso

Paul T Kotnik

John Hicks Dumas, Iii

Zaheer Parpia

Tom Westberg

Mark James Fisher

Sujit Rao Jangam

Arman Nabatiyan

Ashley Marie Yanchak Boggiano

Samuel John Pickerill

Shivani Gupta

John Hicks Dumas

Lawrence Markus

Lawrence W Markus

Ashley Danielle Cramer

Jacqueline R Groves

John H Dumas

John Hicks Dumas Iii

Ashley D Cramer

To detect air in a fluid delivery line of an infusion system, infusion fluid is pumped through a fluid delivery line adjacent to at least one sensor. A signal is transmitted and received using the at least one sensor into and from the fluid delivery line. The at least one sensor is operated, using at least one processor, at a modified frequency which is different than a resonant frequency of the at least one sensor to reduce an amplitude of an output of the signal transmitted from the at least one sensor to a level which is lower than a saturation level of the analog-to-digital converter to avoid over-saturating the analog-to-digital converter. The signal received by the at least one sensor is converted from analog to digital using an analog-to-digital converter. The at least one processor determines whether air is in the fluid delivery line based on the converted digital signal.

Infusion system and method of use which prevents over-saturation of an analog-to-digital converter

Devices for use in extracting an analyte of interest from a sample are described. In one embodiment, a device is comprised of a first plurality of chambers, where one or more chambers in the plurality of chambers has a deep end and a shallow end with a depth d. A channel disposed between at least two adjacent chambers in the plurality of chambers has a depth greater than d. The dimensions of the chamber and channel provide control of fluid movement in the device, particularly when introducing fluid into the device for its use and during use of the device.

Device with controlled fluid dynamics, for isolation of an analyte from a sample

The present invention provides systems, devices, kits, and methods for separating blood plasma from whole blood. In particular, the present invention provides systems, devices, and methods for separating a fixed volume of blood plasma from whole blood with minimal energy input.

Devices and methods for filtering blood plasma

A device for extraction or isolation of an analyte, such as a nucleic acid, a protein, or a cell, from a sample, and in particular from a biological sample is described. Methods of using the device are also described.

Device for isolating an analyte from a sample, and methods of use

An infusion system includes a pump, a fluid delivery line, at least one sensor, a processor, and a memory. The fluid delivery line is connected to the pump for delivering fluid. The at least one sensor is connected to the fluid delivery line for emitting and receiving signals to detect whether there is air in the fluid delivery line. The processor is in electronic communication with the pump and the at least one sensor. The memory is in electronic communication with the processor. The memory comprises programming code for execution by the processor. The programming code is configured to determine a percentage of the air within an observed volume of the fluid delivery line.

Froth detection system and method

An infusion system includes a pump, a fluid delivery line, a sensor, a processor, and a memory. The fluid delivery line is connected to the pump for delivering fluid. The sensor is connected to the fluid delivery line for emitting and receiving signals to detect whether there is air in the fluid delivery line. The processor is in electronic communication with the pump and the sensor. The memory is in electronic communication with the processor. The memory includes programming code for execution by the processor. The programming code is configured to analyze the signals to determine if a stuck fluid droplet is stuck within the fluid delivery line at a location of the sensor.

Pattern recognition system and method for the detection of stuck fluid droplets in a fluid delivery line of an infusion system

The present invention relates to systems, devices, and methods for performing biological reactions. In particular, the present invention relates to the use of lipophilic, water immiscible, or hydrophobic barriers in sample separation, purification, modification, and analysis processes.

Barriers for facilitating biological reactions

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Evanston, IL, United States of America

Kunal Sur