Institute for Basic Science

Taewoong Medical Co., Ltd.

The Catholic University of Korea Industry-Academic

Other

Snu Rdb Foundation

The Catholic University of Korea Industry-Academic Cooperation Foundation

Hanwha Chemical Corporation

H&a Pharmachem Co., Ltd

Panaxem Co., Ltd.

Kyong-min Shin

Snr R&db Foundation

Cathloic University Industry Academic Cooperation Foundation

Enbiar Inc.

Pce Tech Co., Ltd.

Shin, Kyong-min

Kun Na

Taeghwan Hyeon

Daishun Ling

Wooram Park

Dong-Ki Lee

Kyong-Min Shin

Don-Haeng Lee

Sin-Jung Park

Byung Hyo Kim

Hyeona Yim

Yang Lu

Eun-ae Jo

Kyoung Sub Kim

Michael J Hackett

Yong Sun Jeon

Dahye Kim

Hong Geun Ji

Hyung Sun Park

Hyo Gyoung Yu

Young Rong Woo

Se Hee Jo

Hyeon A Yim

Fang Yuan Li

Byoung Chan Bae

Jeong Dong Kim

Jeongdeok Seo

Minji Ahn

Byeong Nam Im

Sin Jung Park

Eun-Ae Jo

The present invention relates to pH-sensitive carbon nanoparticles, a method of preparing the same, and a drug delivery using the same, and pH-sensitive carbon nanoparticles including imidazole is prepared so that a hydrophobic drug and a photosensitizer material can be encapsulated, drug release is possible under weakly acidic conditions, and thus it can be used as a drug carrier for anticancer treatment, photodynamic therapy, or photomediated anticancer immunotherapy.

pH-sensitive carbon nanoparticles, preparation method therefor, and drug delivery using same

The present invention relates to a polymer complex for recognizingand its uses, and in more detail, a water-soluble polymer-photosensitizer complex in which sialyllactose, which selectively binds to the surface of, is conjugated, has excellent selectivity and binding power to thestrain, and the photosensitizer in the complex generates singlet oxygen when irradiated with laser to effectively induce the inactivation ofand it is intended to provide the complex as a polymer complex for recognizingto effectively detectin the gastrointestinal tract and to provide aphotodynamic therapy to solve the conventional antibiotic resistance problem.

Polymer composite for helicobacter pylori recognition and composition for photodynamic therapy comprising same

The present invention relates to a nanoformulated self-assembled pharmaceutical composition for photodynamic therapy. More particularly, the present invention is directed to a self-assembled pharmaceutical composition for photodynamic therapy comprising a photosensitizer, a ligand A which is separated at a specific pH range, and a ligand B of which surface charge changes at a specific pH range and a method for manufacturing the same.

Self-assembled pharmaceutical composition for photodynamic therapy

A gene nanocomposite and a cellular internalization method of a gene using the same are provided. More specifically provided is a gene nanocomposite including: a photosensitizer-conjugated polymer; and one or more materials selected from a gene and a gene/cationic polymer composite, and a cellular internalization method of a gene using the same to improve gene delivery efficiency into a mammal-derived cell and gene expression.

Gene nanocomposite, and cellular internalization method of gene using same

The present invention relates to MRI contrasting agent for contrasting cancer cell which contains ultrafine nanoparticles. More particularly, the present invention is directed to a self-assembled ligand composition comprising a ligand A, which is separated at a specific pH range, and a ligand B of which surface charge changes at a specific pH range, MRI contrast agent for contrasting cancer cell comprising said ligand composition and MRI contrasting nanoparticles, and the methods for preparing them.

MRI contrasting agent for contrasting cancer cell

The present invention relates to a liposome composition comprising 0.001 to 5% by weight of conjugate of lysophophatidylcholine and chlorin e6, 1 to 10% by weight of sucrose laurate, 0.1 to 5% by weight of sodium stearoyl glutamate, 1 to 10% by weight of PEG-5 rapeseed sterol, 1 to 20% by weight of medium-chain triglyceride, 1 to 10% by weight of vegetable oil, 0.1 to 5% by weight of sodium deoxycholate, 3 to 10% by weight of glycerin and the balance of water, and a skin care composition comprising the same. The liposome composition of the present invention is very effective in the treatment of acne.

Liposome composition for treating acne containing conjugate of lysophosphatidylcholine and chlorin e6

Provided are a mussel adhesive protein-mimetic dispersion stabilizing agent to disperse nanoparticles in an aqueous medium, a colloidal solution including nanoparticles dispersed and stabilized by the dispersion stabilizing agent, and a contrast agent including the colloidal solution. More particularly, the mussel adhesive protein-mimetic dispersion stabilizer is a polyethyleneimine-graft-(poly-ethyleneglycol;polyDOPA) PEI-graft-(PEG;PDOPA). The graft polymer is formed of two parts. One is polyethyleneglycol grafted with a polyethyleneime which has an affinity to an aqueous medium, and the other is polyDOPA which has an affinity to the surface of nanoparticles. Because of those characteristics, the stabilizer shows a stable dispersion of nano particles in the aqueous medium.

Biocompatible agent for dispersing nanoparticles into an aqueous medium using mussel adhesive protein-mimetic polymer

Disclosed are a gadolinium complex formed by coordination of gadolinium to the diethylenetriaminepentaacetic acid dianhydride (DTPA) moiety of a pullulan-DTPA conjugate formed by an ester bond between pullulan and DTPA, a preparation method thereof, an MRI contrast composition comprising the complex, and a method of providing information for diagnosis of disease using the complex as an MRI contrast agent. The pullulan-DTPA-Gd complex has a long in vivo half-life, low toxicity, and high MRI signal intensity resulting in clear MRI images, compared to prior gadolinium complexes, indicating that it is advantageously used as an MRI contrast agent. In addition, it is possible to obtain MRI images allowing one to differentiate between diseased liver tissue and normal liver tissue, indicating that it is used as an MRI contrast agent for the liver.

Gadolinium complex, method for preparing same, and MRI contrast agent comprising same

The present invention relates to a conjugate of acetylated biocompatible polysaccharide and phthalocyanine-based compound for photodynamic diagnosis or therapy in which biocompatible polysaccharide is acetylated and a phthalocyanine-based compound is bound to the acetylated polysaccharide. The conjugate for photodynamic diagnosis or therapy according to the present invention is characterized in that the polysaccharide is acetylated to improve solubility in a solvent and thus enable various chemical modifications, and the conjugate may specifically target tumor cells, has superior cancer cell selecting and accumulating capacity, and has excellent effects of killing cancer cells when near infrared ray is irradiated. The conjugate of the present invention may not show cytotoxicity for cells other than cancer cells even when near infrared ray is irradiated, and thus exhibits superior in vivo stability, and therefore, may be valuably used in disease diagnosis or therapy using photodynamics.

Conjugate for photodynamic diagnosis or therapy and method for preparing same

Disclosed are a coating agent for drug releasing stents, a method for preparing the same and a drug releasing stent coated therewith. The coating agent comprises a biologically active material and a coating material selected from among pullulan acetate, represented by the following Chemical Formula 1, and a polyurethane-surfactant mixture. 

Coating agent for drug releasing stent, preparation method thereof and drug releasing stent coated therewith

Disclosed are a coating agent for drug releasing stents, a method for preparing the same and a drug releasing stent coated therewith. The coating agent for drug releasing stents comprises nanoparticles with a biologically active material entrapped therein, wherein the particles are formed of a polyethyleneimine (PEI)-deoxycholic acid (DOCA) polymer (PDo) in which 1&#x2dc;8 moles of DOCA are grafted per mole of PEI.

Growing community of inventors

Bucheon-si, South Korea

Kun Na