Cspc Zhongqi Pharmaceutical Technology (shijiazhuang) Co., Ltd.

Kun Li

Ying Shi

Xuebin Zhao

Jian Lv

Zan Xie

Yuxiu Ma

Xiuqin Yu

Ming Jia

Intermediates of Ertapenem of formula 2a wherein Np represents (I) or (II), and Pand Prepresent carboxyl protecting groups, and their preparation methods. Compound 2a prepared by the present methods in solid form is amorphous. The present invention also relates to a composition comprising at least 95% of the intermediate of Ertapenem of formula 2a. 

Intermediate of Ertapenem, a composition comprising the same and preparation methods thereof

Provided is a crystalline form E of ertapenem sodium. Further provided is a method for preparing a crystalline form E of ertapenem sodium, characterized by using an aqueous ertapenem sodium solution at a low concentration as a raw material. The crystalline form E can be easily filtered and dried, the properties in the drying process are stable, and the purity of the crystal is high and can be up to 98.5% or higher.

Crystalline form of ertapenem sodium and preparation method therefor

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Hebei, China

Kun Li