Yamanouchi Pharmaceutical Company Ltd.

Kumiko Shibasaki

Akihiro Tanaka

Takeshi Murakami

Noriyuki Kawano

Wataru Uchida

Akira Matsuhisa

Masaharu Asano

Shuichi Sakuda

4,4-difluoro-2,3,4,5-tetrahydro-1H-1-benzoazepine compounds or salts thereof and pharmaceutical compositions containing 4,4-difluoro-2,3,4,5-tetrahydro-1H-1-benzoazepine compounds, or salts thereof, and a pharmaceutically acceptable carrier. The chemical structure of these compounds is characterized by a difluoro group on a ring carbon atom adjacent to an azepine ring carbon atom substituted with a methylidene group. Pharmaceutical compositions containing these compounds are particularly useful as oxytocin antagonists and are effective in inhibiting threatened premature birth or abortion and precesarean birth, and are effective as a remedy for dysmenorrhea and other such conditions.

4,4-difluoro-2,3,4,5-tetrahydro-1H-1-benzoazepine derivatives and drug compositions containing them

Therapeutic agents for ischemic heart diseases are provided and contain as an effective component a glutathione monoalkyl ester. The invention is also directed to the use of such therapeutic agents for the treatment of ischemic heart diseases.

Therapeutic agents for ischemic heart diseases

Growing community of inventors

Tsukuba, Japan

Kumiko Shibasaki