Fujisawa Pharmaceutical Company, Ltd.

Kumiko Nitta

Masakuni Okuhara

Yasuhisa Tsurumi

Chiyoshi Kasahara

Nobuharu Shigematsu

Motohiro Hino

Akihiko Fujie

Toshiro Iwamoto

Masashi Hashimoto

Kazuo Sakane

Kohji Kawabata

Hiroshi Hatanaka

Seiji Hashimoto

Hidenori Ohki

Itsuo Uchida

Hidetsugu Murai

A compound having antimicrobial activity of the following general formula: ##STR1## wherein R.sup.1 is hydrogen or hydroxy, R.sup.2 is hydrogen or hydroxy, R.sup.3 is hydroxy or hydroxysulfonyloxy, with proviso that when R.sup.1 is hydrogen, R.sup.2 is hydrogen, or a phamaceutically acceptable salt thereof. The compound can be used in a method for treating infectious diseases caused by pathogenic microorganism.

Antimicrobial polypeptide compound a pharmaceutical composition

A polypeptide compound having antimicrobial activity of the following general formula: ##STR1## wherein R.sup.1 is hydrogen or acyl group, R.sup.2 is hydroxy or acyloxy,

Polypeptide compound and a process for preparation thereof

This invention relates to new carboxylic acid derivatives of the formula: ##STR1## wherein R.sup.1 is hydrogen, lower alkyl or aryl, and pharmaceutically acceptable salt thereof which inhibit activity of DHP-I, to a process for preparing them and to an antibacterial composition comprising them and carbapenem antibiotics.

Carboxylic acid derivatives

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Tsuchiura, Japan

Kumiko Nitta