Nihon Medi-physics Company, Limited

Kumiko Iwai

Makoto Azuma

Shigemi Seri

Susumu Kondo

Yuji Hashiguchi

A gadolinium complex of 1,4,7,10-tetraazacyclododecane-1,4,7,10-.alpha.,.alpha.',.alpha.',.alpha.' '-tetrakis(methylacetic acid) or its salt, which is useful as a nuclear magnetic resonance imaging agent.

Method of NMR imaging

There is disclosed an imaging agent for diagnosis comprising a compound composed of a polynuclear type compound of the formula I or II: ##STR1## wherein each X is a hydrogen atom or a bifunctional ligand, at least one of them are bifunctional ligand and m or n is an integer of 1 to 6, and at least one metal ion being coordinated with at least one bifunctional ligand moiety, said metal ion being selected from the group consisting of metal ions having the atomic number of 21-29, 31, 32, 37-39, 42-44, 49 and 56-83.

Low molecular weight polysaccharide complexes for radiation diagnosis

There is disclosed an imaging agent for diagnosis comprising a compound composed of a polynuclear type compound of the formula I or II: ##STR1## wherein each X is a hydrogen atom or a bifunctional ligand, at least one of them are bifunctional ligand and m or n is an integer or 1 to 6, and at least one metal ion being coordinated with at least one bifunctional ligand moiety, said metal ion being selected from the group consisting of metal ions having the atomic number of 21-29, 31, 32, 37-39, 42-44, 49 and 56-83.

Low molecular weight polysaccharide complexes for X-ray imaging

Low molecular weight polysaccharide complexes for nuclear magnetic

There is disclosed a nuclear magnetic resonance imaging agent comprising a complex compound composed of (a) a dialdehyde-saccharide having a molecular weight of from 500 to 10,000, at least one of the constituent monosaccharides of which is oxidation-cleaved, (b) at least one complexing agent which is chemically coupled to an aldehyde group of the dialdehyde-saccharide and (c) a paramagnetic metal ion which is chemically coupled to the complexing agent.

Growing community of inventors

Ichihara, Japan

Kumiko Iwai