Ishihara Sangyo Kaisha, Ltd.

Kumiko Azuma

Takashi Okada

Masayuki Morita

Kazuhiro Yamamoto

Hirohiko Kimura

Fuminori Kato

Taku Hamamoto

Mitsuo Sano

Toshihiko Ueki

Kiyoshi Tamai

Shinya Mori

To provide cytokine production inhibitors useful as preventive or therapeutic medicines for diseases accompanied by hyperactivated immune functions. A cytokine production inhibitor containing, as an active ingredient, a thioamide compound represented by the formula (I) or a salt thereof: wherein A is N, NO, C&#x2014;NOor C&#x2014;CN; Hal is a halogen; Mis alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, heterocyclyl, amino, O, S, SO or SO; Mis amino, O, S or a single bond; Ris a halogen, alkyl or the like; each of R, R, Rand Ris independently H, alkyl or the like; Ris a halogen, alkyl or the like; Cy is cycloalkyl, cycloalkenyl, aryl or heterocyclyl; each of k, p and q is independently an integer of from 0 to 3; and r is an integer of from 0 to 5.

Thioamides and salts thereof and cytokine production inhibitors containing both

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Kusatsu, Japan

Kumiko Azuma