Hisamitsu Pharmaceutical Company, Inc.

Kumi Morimoto

Kenji Ishigaki

Akio Takeuchi

Seiji Tokumoto

Takashi Yasukochi

Naoki Yamamoto

Toshiyuki Matsudo

Shinpei Nishimura

Satoshi Amano

Arata Toshimitsu

Kaori Yamaguchi

A transdermal preparation comprising a multivalent metal chloride, a basic drug having an amino group, and an ester group-containing base material, is useful because of its excellent drug content stability.

Transdermal preparation

Provided is a medicated patch containing a medicinal agent, an adhesive base material and a tackifier, where the medicinal agent is varenicline or a pharmaceutically acceptable salt thereof, the adhesive base material is a rubbery adhesive base material and the tackifier is a rosin-based tackifier selected from the group consisting of rosin, rosin derivatives and hydrogenated products of the foregoing, or a non-rosin-based tackifier selected from the group consisting of aliphatic hydrocarbon resins and alicyclic hydrocarbon resins, and when a non-rosin-based tackifier is added as the tackifier, a solubilizer for the medicinal agent is further added, the solubilizer containing an alcohol-based solubilizer having at least a solubility parameter of 20-35.

Medicated patch

Provided is a medicated patch containing a medicinal agent and an adhesive base material and having an acid value of no greater than 28, where the medicinal agent is varenicline or a pharmaceutically acceptable salt of varenicline.

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Tsukuba, Japan

Kumi Morimoto