Kyorin Pharmaceutical Co., Ltd.

Kumi Ishikawa

Yasushi Kohno

Yasuo Takano

Kiyoshi Fujii

Tsuyoshi Anraku

Futoshi Shiga

Tetsuya Kimura

Shigeru Koga

Ken Yoshikawa

Takahiro Kanda

Jyunichi Ishiyama

Tomoyuki Kawai

[Problem] To provide a diphenyl sulfide derivative which is useful as a pharmaceutical product that has excellent S1P3 antagonist activity. [Solution] The inventors have discovered that a diphenyl sulfide derivative represented by general formula (1) (wherein R1 represents an alkoxy group having 1-6 carbon atoms, R2 represents a propyl group or an allyl group, X represents methylene or an oxygen atom, and Z represents a halogen atom) has excellent S1P3 antagonist activity as a result of extensive researches for the production of a compound that has S1P3 antagonist activity. 

Diphenyl sulfide derivative and pharmaceutical product which contains same as active ingredient

The invention provides 4-substituted aryl-5-hydroxyisoquinolinone derivatives and their pharmacologically acceptable addition salts with excellent inhibitory effect on poly (ADP-ribose) synthetase. 4-Substituted aryl-5-hydroxyisoquinolinone derivatives, represented by a general formula (1) and their pharmacologically acceptable addition salts.

4-(Substituted aryl)-5-hydroxyisoquinolinone derivative

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Tochigi, Japan

Kumi Ishikawa