Defence Research Development Organisation

The Director General, Defence Research and Development Organisation

The Chief Controller, Research and Development, Defence Research and Development Organization of Ministry Defence

Kumaran Ganesan

Krishnamurthy Sekhar

Ramesh Chandra Malhotra

Pradeep Kumar Gupta

Chandra Ramesh Malhotra

Vaidyanatha Ramamoorthy Swamy

Singh Balwant Batra

Balwant Singh Batra

Shri Prakash

Asheesh Kumar Jain

Ambati Narasimha Rao

Vinita Dubey

Ambuja Pande

Laxmi Manral

Rajagopalan Vijayaraghavan

Murlidhar J Mendki

Brahma Dutt Parashar

Kshitij Chandel

Natarajan Gopalan

The invention provides a method for the preparation of fentanyl comprising: (a) reacting 4-piperidone hydrochloride monohydrate with aniline in presence of reducing environment to produce 4-anilinopiperidine (4-AP), (b) reacting the 4-AP as obtained from step (a) with phenethyl halide under reflux conditions in highly alkaline medium to give 4-anilino-N-phenethylpiperidine, and (c) converting the 4-anilino-N-phenethylpiperidine to fentanyl by reacting with propionyl chloride in presence of halogenated hydrocarbons, then isolating fentanyl by solvent extraction and purifying by crystallization from petroleum ether at a temperature ranging from 60-80&#xb0; C.

Method for the preparation of fentanyl

An improved process for the preparation of 2-chlorobenzylidenemalononitrile (CS) comprising of the steps of: preparing malononitrile suspension by adding 5-20% (wt %) preferably 12-14% malononitrile to water while constantly stirring and then adding 0.05-0.5% (v/v) preferably 0.1-0% of a catalyst like piperidine, pyridine, 2-picoline, 3-picoline, 4-picoline or morpholine preferably piperidine piperidine with constant stirring at 20-30&#xb0; C.; condensing the malononitrile suspension prepared in step (a) with 2-chlorobenzaldehyde by adding 10-15% (w/v) preferably 25-30%, of 2-chlorobenzaldehyde cover a period at 30-45 minutes so that the temperature of the reaction mixture remains below 50&#xb0; C., constantly stirring for 20-40 minutes, then filtering the CS and drying it at 20-30&#xb0; C. under water vacuum for 3-5 hrs.

Eco-friendly process for the preparation of 2-Chlorobenzylidene-Malononitrile (CS)

A process for the preparation of n-heneicosane is disclosed. The process comprises (a) reacting 2,4-alkaneanedione with 1-bromooctadecane in absolute ethanol in the presence of 18-crown-6 as catalyst to produce 2-heneicosanone; and (b) reducing said 2-heneicosanone using hydrazine hydrate and potassium hydroxide in ethylene glycol to obtain n-heneicosane.

Process for the preparation of n-heneicosane

A process for the complete destruction of gelled sulphur mustard (SM), comprising the steps of: (a) dissolving gelled sulphur mustard (SM) in organic solvent such as 2-chloroethanol, methanol, methyl cellosolve or mixtures of these to obtain a clear mixture, (b) incinerating the clear gelled sulphur mustard solvent mixture obtained from step (a); (c) dissolving residual gelled SM obtained from step (c) into non-toxic products; (d) chemically converting dissolved SM obtained from step (c) into non-toxic products.

Process for destruction of gelled sulphur mustard

A process for the chemical destruction of sulphur mustard by chemical conversion which comprises in the step of reacting sulphur mustard with a thiophilic agent prepared by dissolving sulphur in ethylenediamine and/or ethanol diamine.

Process for chemical destruction of sulphur mustard

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Gwalior, India

Kumaran Ganesan