Lupin, Inc.

Kumar Ram Naik

Rajender Kumar Kamboj

Kamlesh Jyotindra Padiya

Bhavani Shankar Rajesh

Barve Sitaram Rambhau

Ganpati Powar Rajendra

Subhash Ingawale Sachin

Prabakaran Kamalakannan

Spinvin Venugopal

Kamalakannan Prabakaran

Sachin Subhash Ingawale

Dattatray Karche Amit

Rajendra Ganpati Powar

Shankar Dange Santoshkumar

Shaji George Kochumalayil

A process for manufacturing substituted chroman compounds in an economically scalable manner, without the use of pyrophoric reagents. Also disclosed herein are chroman compound synthesis routes that do not include column chromatography purification steps. The disclosure also relates to the intermediates used in the synthesis. In particular, the disclosure relates to the synthesis of the Calcium sensing receptor (CaSR) modulating agent 2-methyl-5-((2R,4S)-2-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoic acid, its intermediates and pharmaceutically acceptable salts thereof.

Process for preparing chroman compounds

This disclosure describes an economical and scalable method and process to synthesize the Calcium sensing receptor (CaSR) modulating agent 2-methyl-5-((2R,4S)-2-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoic acid, its intermediates and pharmaceutically acceptable salts therefor. Uses of said intermediates for synthesis of compounds which may be intermediates to the synthesis of 2-methyl-5-((2R,4S)-2-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoic acid are also described herein.

Methods, processes and intermediates for preparing chroman compounds

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Pune Maharashtra, India

Kumar Ram Naik