Other

Arcturus Therapeutics, Inc.

Kumar Rajappan

Padmanabh Chivukula

Steven Paul Tanis

Priya Prakash Karmali

Kiyoshi Tachikawa

ASGP-R binding molecular conjugates are provided. The conjugates are useful to deliver therapeutically effective amounts of biologically active molecules to target cells and tissues of a subject. Compositions are also provided comprising the molecular conjugates.

Asialoglycoprotein Receptor mediated delivery of therapeutically active conjugates

A class of phosphorus containing polycyclic compounds of general formula I, of general formula I' or of general formula I&#x2033;, wherein B, B, R, R, R, X, X, Y, Y, B, B, Z, and Zare defined herein, that may be useful as modulators of type I interferon production, specifically as STING modulating agents, are provided. Also, provided are use of such compounds.

Immune modulatory compositions

A class of phosphorus containing polycyclic compounds of general formula I, of general formula I' or of general formula I&#x2033;, wherein B, B, R, R, R, X, X, Y, Y, B, B, Z, and Zare defined herein, that may be useful as modulators of type I interferon production, specifically as STING modulating agents, are provided. Also, provided are use of such compounds. 

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San Diego, CA, United States of America

Kumar Rajappan