Korea Institute of Science and Technology

Kuiwon Choi

Ick Chan Kwon

Inchan Youn

Kwang Meyung Kim

Hyung Min Kim

Sehoon Kim

Kwangmeyung Kim

Jun-Kyo Francis Suh

Heebeom Koo

Sang-min Lee

Jinseok Kim

Jeong Hwan Kim

Jinwoo Jeong

Seung-Jong Kim

Jung Kyu Kim

Ick-Chan Kwon

Yong-Hee Kim

So Jin Lee

Jae Bong Choi

Sunghee Park

In Chan Youn

Hyung Jun Ahn

Seo Young Jeong

Hyun Su Min

Chang-Keun Lim

Kyu Back Lee

Sojin Lee

Myung Sook Huh

Heesu Park

Youn Joo Lee

Tae Soo Bae

Chang Yang Lee

Suh-Yeon Dong

Hyunmyung Cho

Kwangmyeng Kim

MyungSook Huh

Inwon Jung

Seung Young Lee

Myungn Sook Huh

Sang-Min Lee

The present invention relates to a stress analysis method including: acquiring bio-signals from a test subject; calculating a probability of each of a plurality of stress level values by processing the bio-signals using a deep neural network algorithm; estimating a stress level value with the maximum probability of the plurality of stress level values as a stress level value of the test subject; determining usefulness of the estimated stress level value; and outputting the estimated stress level value determined to be useful through the determination of usefulness, as the final stress level.

Method for real time analyzing stress using deep neural network algorithm

Disclosed is an apparatus for measuring electrocardiogram (ECG) using wireless communication, including a first measuring device and a second measuring device connected to each other using wireless communication, wherein the first measuring device includes a first electrode configured to measure a first signal generated by a heartbeat, and a slave signal generation unit configured to generate a slave signal based on the first signal and a wireless virtual ground signal received from the second measuring device, and the second measuring device includes a second electrode configured to measure a second signal generated by a heartbeat, a ground electrode configured to measure a ground signal, a wireless virtual ground unit configured to generate the wireless virtual ground signal based on the ground signal, and an ECG measuring unit configured to measure ECG based on the slave signal, the second signal, and the wireless virtual ground signal.

Apparatus and method for measuring electrocardiogram using wireless communication

The present disclosure relates to a method for in vivo targeting of a nanoparticle via bioorthogonal copper-free click chemistry, more particularly to a method for in vivo targeting of a nanoparticle, including: injecting a precursor capable of being metabolically engineered in vivo when injected into a living system and having a first bioorthogonal functional group into the living system; and injecting a nanoparticle having a second bioorthogonal functional group which can perform a bioorthogonal copper-free click reaction with the first bioorthogonal functional group attached thereto into the living system. In accordance with the present disclosure, accumulation of nanoparticles at a target site in a living system can be increased remarkably and the biodistribution of the nanoparticles can be controlled since the nanoparticles bound to a cell surface are taken up into the cell with time.

Method for in vivo targeting of nanoparticles via bioorthogonal copper-free click chemistry

A tumor-targeting gas-generating nanoparticle, a method for preparing same and a tumor-targeting nanoparticle for drug delivery using same relate to a tumor-targeting gas-generating nanoparticle including a polycarbonate core and a amphiphilic coat, a method for preparing same and a tumor-targeting nanoparticle for drug delivery using same. Since a tumor-targeting gas-generating nanoparticle according to the present disclosure is accumulated in the tumor tissue in large quantity and generates strong ultrasound wave signals, it can be usefully used as a contrast agent for ultrasonic imaging.

Tumor-targeting gas-generating nanoparticle, method for preparing the same, and tumor-targeting nanoparticle for drug delivery using the same

A neural tube capable of complexly playing roles of a support for regenerating a nerve and a nerve electrode has a support connected to a terminal of an injured nerve, and a sieve electrode having an electrode hole formed in a body thereof and a circular electrode formed around the electrode hole, wherein the body of the sieve electrode is buried in the support, wherein a cavity-type channel is formed at the support to extend to the inside of the support, wherein the electrode hole is aligned with the channel, and wherein a nerve cell growing along the channel at the terminal of the injured nerve is capable of contacting the circular electrode.

Neural tube for recovering function of injured nerve

Disclosed is a polymer-siRNA delivery carrier in which a siRNA is combined with a polymer and the use thereof. More specifically, there is disclosed a stable in vivo polymer-siRNA delivery carrier in which a polymer and a siRNA are combined by using charge interaction and biodegradable covalent bonding at the same time and the use thereof. The polymer-siRNA delivery carrier in which a polymer and a siRNA are combined by using charge interaction and biodegradable covalent bonding at the same time has a high siRNA deliver efficiency to a target portion in vivo. Hence, according to the polymer-siRNA binder, the siRNA for treatment can be effectively delivered to a target portion such as in vivo cancer tissue, and the like even with administration of a relatively low concentration, and thus widely used for the treatment of various kinds of diseases.

Polymeric nano-particles for siRNA delivery using charge interaction and covalent bonding

The present invention relates to recombinant albumins fused with poly-cysteine peptide and methods for preparing the same, more precisely recombinant albumins in which cysteines that can be used for drug binding are amplified at N-terminal and C-terminal of the albumin and methods for preparing the same. The recombinant albumin of the present invention demonstrates improved albumin-drug conjugation efficiency when it is used for drug delivery system, indicating that it can effectively deliver a large amount of drug to a target tissue. At the same time, the recombinant albumin of the present invention can be used as an excellent drug deliverer with reduced side effects, compared with the conventional albumin carriers, by regulating the amount of drug conjugated to each unit of albumin by regulating the number of cysteine fused thereto. In addition, the recombinant albumin of the present invention can be used for the screening of a novel drug and for the non-invasive real-time diagnosis and treatment of disease by combining with a fluorescent material or a contrast agent for molecular imaging.

Recombinant albumins fused with poly-cysteine peptide and the methods for preparing the same

Disclosed are a human serum albumin-siRNA carrier system having siRNA bound to human serum albumin and a user thereof, and especially, human serum albumin-siRNA carrier system, which has a biodegradable covalent bond between human serum albumin polymer and siRNA and is stable in a living body, and a user thereof. The human serum albumin-siRNA carrier system having the biodegradable covalent bond between the human serum albumin and the siRNA exhibits high siRNA delivery efficiency to a target site in the living body. Therefore, the human serum albumin-siRNA carrier system may allow siRNA for therapy to be efficiently delivered to a target site such as cancer tissues in the living body even by being administrated in a relatively low concentration, which may result in a wide use for therapies of various diseases.

Human serum albumin-siRNA nano-sized carrier system

Disclosed are nanoparticles of a light emissive polymer, comprising nanoparticles of a cyano-substituted poly(arylene vinylene) polymer; and a biocompatible surfactant adsorbed to the surface of the nanoparticles of the polymer, and preparation method thereof, wherein the method comprises: (1) uniformly mixing a dialdehyde monomer represented by a general formula OHC&#x2014;Ar&#x2014;CHO, a dicyanide monomer represented by a general formula NC&#x2014;Ar&#x2014;CN, and a liquid surfactant; (2) adding water to the resulting mixture to prepare an aqueous micelle dispersion; and (3) adding a polymerization catalyst to the aqueous micelle dispersion, followed by carrying out colloidal polymerization of the resulting mixture at room temperature under an atmosphere. The nanoparticles of the light emissive polymer of the invention are stabilized with a biocompatible surfactant, so that it can form a stable aqueous dispersion phase, and has particle size and fluorescence efficiency suitable for a biomolecular marker or a cell or in vivo imaging; therefore, it can be used as a cell or in vivo light emission contrast agent.

Nanoparticles of light emissive polymers and preparation method thereof

A hybrid bioreactor for cell culture is disclosed. To simultaneously apply compressive strain for cell differentiation and shear strain for cell proliferation to cells, the hybrid bioreactor includes a plurality of reactor tube assemblies (), a compressive strain motor (), a shear strain motor (), a lower anchor mount () having a plurality of toothed anchors () to respectively anchor the lower ends of the reactor tube assemblies () to the lower anchor mount (), a ball screw () operated in conjunction with the compressive strain motor (), an upper anchor mount () which engages with the ball screw () to vertically move upward and downward and having a plurality of compressive strain anchors () to anchor the upper ends of the reactor tube assemblies () to the upper anchor mount (), a power transmission unit to transmit the rotating force of the shear strain motor () to the toothed anchors ().

Hybrid bioreactor for cell culture

A method of manufacturing a porous matrix-type drug delivery system is provided. It comprises the steps of: dispersing, stirring, and emulsifying an aqueous solution of a drug in an organic solvent having a polymer compound and a surface active agent solved therein; thereafter forming it into a desirable matrix shape; lyophilizing or drying it at a low temperature or room temperature until the matrix surface is hardened; and drying it again in order to remove the water and the organic solvent.

Method of manufacturing porous matrix-type controlled release systems using emulsion technique

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Seoul, South Korea

Kuiwon Choi