Mine Safety Appliances Company

Kuen-Wai Chiu

David H Ellenberger

Mary H Staruch

John R Strickler

Lin-Chen Yu

Joseph M Barendt

A one-step synthesis of an alkali-metal hexamethyldisilazane is provided in which an alkali metal selected from the group consisting of lithium, sodium and potassium is reacted with 1,1,1,3,3,3,-hexamethyldisilazane at a reaction temperature above the melting point of the alkali metal without the use of an electron carrier, alkali-metal derivatized reagents, such as alkyl-aryl organometals, alkali-metal amides and alkali-metal hydrides, or a catalyst.

Preparation of alkali-metal hexamethydisilazanes

.alpha.-Arylalkanoic acids are prepared by a method comprising the step of reacting an alkylaromatic compound corresponding to the desired .alpha.-arylalkanoic acid with a new metallation reagent solution. The reagent comprises the reaction product of alkyllithium or aryllithium and about two to five molar equivalents of potassium tert-alkoxide in a trialkylamine solvent.

Strong base reagent

Indole and indole derivatives are prepared by contacting under mild reaction conditions an N-(2-toly)formidate, N-(3-methyl-2-pyridyl)formimidate, or N-methyldiazyl formimidate with an alkali metal amide.

Preparation of indole and indole derivatives

Process for the preparation of .alpha.-arylalkanoic acids

Potassium hydride and mixtures of potassium hydride with other alkali metal hydrides are prepared by contacting hydrogen with potassium or potassium alloys with other alkali metals, dispersed in an inert fluid, in the presence of a potassium phenanthride catalyst.

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Wexford, PA, United States of America

Kuen-Wai Chiu