Academia Sinica

Kuen-jer Tsai

Che-Kun James Shen

Eminy Hsiao-Yuan Lee

A method for treating a progressive neurodegenerative disorder with bone marrow stem cells and a G-CSF receptor agonist.

Methods for rescuing learning and/or memory deficits caused by alzheimer's disease by G-CSF

Non-human animal models for frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U) are disclosed. The invention relates to a transgenic mouse whose genome comprises a transgene operably linked to a neuronal specific promoter effective for an increased expression of the transgene in the brain of the mouse, in which the transgene comprises a nucleotide sequence encoding TAR DNA-binding protein 43 (TDP-43). The transgenic mouse exhibits reduced or impaired learning and memory capacity, and may further exhibits progressively impaired or reduced motor functions. Methods of using such animal models are also disclosed.

Non-human animal model for frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U)

A method of determining whether a patient is deficient in spatial learning and memory. The method includes providing a sample from the patient, the sample containing an sgk gene product; and determining an sgk expression level in the sample. If the sgk expression level in the sample is lower than that in a sample from a normal person, it indicates that the patient is deficient in spatial learning and memory. Also disclosed are a method of identifying a compound for treating deficiency in spatial learning and memory and a method of treating such deficiency.

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Kaohsiung, Taiwan

Kuen-jer Tsai