Warner-lambert Company

Kuchi S Murthy

Mahdi B Fawzi

Russell U Nesbitt

Gerard C Hokanson

Michael Ray Harris

Surendra C Mehta

Suk-Zu Song

Frank Waldman

Robert G Reisch, Jr

Robert Reisch

Daniel A Kubert

The present invention is a stabilized enteric-coated pharmaceutical dosage form and processes for the preparation thereof. Dissolution stability after storage of the dosage form under high stress conditions is improved by an enteric-coated dosage form having an enteric coating wherein the coating is of the acrylic resin kind of from 14 mg/cm.sup.2 to 24 mg/cm.sup.2 or an enteric coating wherein the coating is of the acetate kind of from 14 mg/cm.sup.2 to 24 mg/cm.sup.2 and having a second coating of hydrophilic coating for example, hydroxypropyl cellulose, hydroxymethyl cellulose or hydroxypropylmethyl cellulose.

Stabilization of enteric coated dosage form

A new series of copolymers which are useful as coatings for solid dosage forms, for transdermal devices, for wound dressing materials, and for contact lenses. Also disclosed are methods for preparing monomers and polymers as well as pharmaceutical compositions containing such polymers.

Methylene pyrrolidone copolymers for contact lens and pharmaceutical

Copolymers from n-alkyl-3-alkenylene-2-pyrrolidone

A new series of copolymers such as N-isopropyl-3-methylene-2-pyrrolidone and 2-hydroxyethylmethacrylate which are useful as coatings for solid dosage forms, for transdermal devices, for wound dressing materials, and for contact lenses. Also disclosed are methods for preparing monomers and polymers as well as pharmaceutical compositions containing such polymers.

N-substituted-3-alkylene-2-pyrrolidone compounds

The oxidation--and color-stability of certain ace inhibitors is optimized when they are formulated with a stabilizer and at least one lubricant and/or excipient.

Drug compositions stabilized against oxidation

The cyclization and hydrolysis of certain ACE inhibitors is minimized when they are formulated with a stabilizer and at least one lubricant and/or excipient.

Stabilized drug compositions

The cyclization, hydrolysis, and coloration of certain ACE inhibitors is minimized when they are formulated with a metal-containing stabilizer and a saccharide.

Growing community of inventors

Morris Plains, NJ, United States of America

Kuchi S Murthy