Eisai R&d Management Co., Ltd.

Epizyme, Inc.

Kuan-Chun Huang

Kevin Wayne Kuntz

Steven Mathieu

Arani Chanda

Kristen Sanders

Hyeong Wook Choi

Francis Gerard Fang

Ming-Hong Hao

Atsushi Endo

Hyeong-wook Choi

Dae-Shik Kim

Frank Fang

Xingfeng Bao

Frances Fang

Provided herein are methods for the treatment of bladder cancer.

Methods for the treatment of bladder cancer

Provided herein is N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl (tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4'-(morpholinomethyl)-[1,1′-biphenyl]-3-carboxamide hydrobromide. Also provided herein is a particular polymorph form of this compound.

Salt form of a human histone methyltransferase EZH2 inhibitor

Provided herein is N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl (tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4'-(morpholinomethyl)-[1,1&#x2032;-biphenyl]-3-carboxamide hydrobromide. Also provided herein is a particular polymorph form of this compound.

Provided herein are compounds useful for the treatment of cancer.

Compounds for the treatment of cancer

Provided herein is N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4'-(morpholinomethyl)-[1,1&#x2032;-biphenyl]-3-carboxamide hydrobromide. Also provided herein is a particular polymorph form of this compound.

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Andover, MA, United States of America

Kuan-Chun Huang