Idexx Laboratories, Inc.

Novo Nordisk A/s

Antyra Inc.

Ku-chuan Hsiao

Melissa Jane Beall

Philip R Andersen

Stacey Pazar Huth

Marilyn Strong-Townsend

Jesse Buch

Barbara O'Brien

Eugene Regis Krah, Iii

Neil I Goldstein

Arthur J Blume

Renee Brissette

Renuka Pillutla

Hao Liu

Olga Dedova

Eugene Regis

Pinger Wang

Michael Lennick

Paul Fletcher

Melissa Jane Beal

Barbara O'Brien Graff

Marylin I Strong-Townsend

Isolated nucleic acid molecules having a nucleotide sequence encoding feline pancreatic lipase polypeptides, splice variants, allelic variants, and fragments thereof. Isolated feline pancreatic lipase polypeptides, splice variants, allelic variants, and fragments thereof. Host cells comprising a vector containing the polynucleotide sequences and methods for expressing the polypeptides. The generation of monoclonal antibodies that specifically binds to the feline pancreatic lipase polypeptides, and cell lines secreting the monoclonal antibodies. Methods for determining the presence or amount of feline pancreatic lipase in a biological sample. The methods include using standards or calibrators of recombinant feline pancreatic lipase to quantify the lipase in a sample. Devices and kits for performing methods for detecting feline pancreatic lipase in biological samples.

Feline pancreatic lipase

Peptide sequences capable of binding to insulin and/or insulin-like growth factor receptors with either agonist or antagonist activity and identified from various peptide libraries are disclosed. This invention also identifies at least two different binding sites, which are present on insulin and insulin-like growth factor receptors, and which selectively bind the peptides of this invention. As agonists, the peptides of this invention may be useful for development as therapeutics to supplement or replace endogenous peptide hormones. The antagonist peptides may also be developed as therapeutics.

Insulin and IGF-1 receptor agonists and antagonists

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Easton, PA, United States of America

Ku-chuan Hsiao