Affymetrix, Inc.

Ksenia Oleinik-Ovod

Mark R Jones

Nathan K Weiner

Christopher Miles

Patrick Odoy

Albert Bukys

David A Stura

Herman Deweerd

Eric E McKenzie

Thomas P Regan

David Bradbury

Tim J Woolaver

Joel M Katz

Roger DiPaolo

James T Overbeck

Eric Schultz

Eric Earl Mckenzie

Patrick J Odoy

An embodiment of a scanning system is described including optical elements that direct an excitation beam at a probe array, detectors that receive reflected intensity data responsive to the excitation beam, where the reflected intensity data is responsive to a focusing distance between an optical element and the probe array, a transport frame that adjusts the focusing distance in a direction with respect to the probe array, an auto-focuser that determines a best plane of focus based upon characteristics of the reflected intensity data of at least two focusing distances where the detectors further receive pixel intensity values based upon detected emissions from a plurality of probe features disposed on the probe array at the best plane of focus, and an image generator that associates each of the pixel intensity values with at least one image pixel position of a probe array based upon one or more position correction values.

System, method, and product for scanning of biological materials

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Newton, MA, United States of America

Ksenia Oleinik-Ovod