The Cleveland Clinic Foundation

Krzysztof Siemionow

Isador H Lieberman

Maria Siemionow

Selvon St Clair

Mark Kayanja

Described herein is conduit material that causes minimal inflammatory reaction, and serves as a structural guide for regenerating nerve tissue (e.g., axons). Thus, the invention is directed to methods of treating a nerve injury in an individual in need thereof. The methods employ an isolated, naturally occurring epineural sheath, and can be used, for example, to regenerate nerve tissue in an individual in need thereof. Also provided herein is a device for harvesting an epineural sheath.

Use of epineural sheath grafts for neural regeneration and protection

A method for augmenting or replacing a spinal facet () includes the steps of providing a first plate () and a second plate (). An elastomeric member () is secured between and to the first plate () and the second plate (). The first plate () is secured to a first vertebra (). The second plate () is secured to a second vertebra () adjacent the first vertebra () for mimicking natural articulation between the first and second vertebrae ().

Facet augmentation

An apparatus for affixing a plurality of body structures together in a flexible manner includes a first articulated fastener having substantially rigid proximal and distal portions, longitudinally separated by a first flexible articulating portion. The first articulated fastener has a first thread direction. A second articulated fastener has substantially rigid proximal and distal portions, longitudinally separated by a second flexible articulating portion. The second articulated fastener has a second thread direction opposite the first thread direction. The first and second articulated fasteners are both adapted for insertion into each of the plurality of body structures. A method of affixing a plurality of body structures together in a flexible manner is also provided.

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Shaker Heights, OH, United States of America

Krzysztof Siemionow