The Cleveland Clinic Foundation

Pharmasset, Inc.

Applied Genetics Incorporated Dermatics

The United States of America

Applied Genetics Incorporated Dematics

Krystyna Lesiak

David A Brown

Wu Yun Ren

Alexander A Khorlin

Robert H Silverman

Kyoichi A Watanabe

Ratan Maitra

Krzysztof W Pankiewicz

Paul Torrence

Disclosed are methods and compositions for regulating the melanin content of mammalian melanocytes; regulating pigmentation in mammalian skin, hair, wool or fur; treating or preventing various skin and proliferative disorders; by administration of various compounds, including alcohols, diols and/or triols and their analogues.

Dermatological compositions and methods

Disclosed are novel bicyclic tris(anhydride)s useful as intermediates in the synthesis of biologically active compounds, and the compounds which may be synthesized from such intermediates.

Tetraphosphonate bicyclic trisanhydrides

Disclosed are methods and compositions for regulating the melanin content of mammalian melanocytes; regulating pigmentation in mammalian skin, hair, wool or fur; treating or preventing various skin and proliferative disorders; by administration of various compounds, including alcohols, diodls and/or triols and their analogues.

Disclosed are novel bicyclic tris(anhydride)s useful as intermediates in the synthesis of biolologically active compounds, and the compounds which may be synthesized from such intermediates.

A method of using a chimeric molecule made up of an antisense oligonucleotide attached to a 2',5'-oligoadenylate molecule to specifically cleave a sense strand of RNA, wherein the antisense oligonucleotide of the chimeric molecule is hybridized to the sense strand of RNA in the presence of 2',5'-dependent RNase.

Growing community of inventors

Gaithersburg, MD, United States of America

Krystyna Lesiak