University of California

Genzyme Corporation

Voyager Therapeutics, Inc.

Brainlab Ag

Krystof Bankiewicz

Adrian P Kells

Kathryn H Rosenbluth

Stefan G Schreck

Stephan Mittermeyer

Janet Cunningham

Kenneth A Bloch

Joseph Doyle

Edward Luttich

Jan Felix Eschermann

The use of stepped cannulas, wherein a step structure creates a backstop to reduce backflow along the cannula body, is known for convection enhanced delivery of agents to the brain and other structures within an animal. Described herein are novel and improved stepped cannula designs wherein the length of the cannula segment between the step and the dispensing outlet is variable and can be controllably adjusted inside the patient during delivery. This advantageously allows the operator to place the cannula step at the optimal position and deliver agents at one or more positions within the target structure.

Adjustable stepped cannula

The invention provides methods for treating neurological disorders, which involve administering therapeutic agents to the thalamus by convection enhanced delivery.

Methods for distributing high levels of therapeutic agent throughout the cortex to treat neurological disorders

The present disclosure provides methods for targeting a biomedical system. Aspects of the subject methods include determining the trajectory of a targeting device using magnetic resonance imaging (MRI) of a MRI-visible style of a trajectory guide that is compatible with the targeting device. Targeted biomedical systems may be utilized for a variety of purposes including targeted delivery of a therapeutic, holding a therapeutic device, positioning of a therapeutic device and other uses. Also provided are devices and systems that can be used in practicing the described methods including but not limited to trajectory guides and adjustable targeting systems, as well as non-transitory computer readable medium storing instructions that, when executed by a computing device, cause a computing device to perform steps of the described methods.

Methods for biomedical targeting and delivery and devices and systems for practicing the same

The present disclosure presents a trajectory array guide system for defining a trajectory to a target location in the brain of a subject and for guiding an elongated tool along the trajectory. The trajectory array guide system can comprise: a base, an array guide, an imaging unit, and an elongated handle configured for connection with a stereotaxic navigation system. The present disclosure presents a method of using a trajectory array guide system for defining a trajectory to a target location in the brain of a subject and for guiding an elongated tool along the trajectory.

Trajectory array guide system

A method and system that is directed to the local delivery of growth factors to the mammalian CNS to treat CNS disorders associated with neuronal death and/or dysfunction is described.

Administration of growth factors for the treatment of CNS disorders

A method for planning an infusion of a medical substance into a target region acquires non-patient-specific anatomical data from an atlas in the form of target region geometry information describing target and off-target regions for which an infusion of the medical substance is intended and regions to be avoided, respectively. Target coverage information is derived describing a minimum dose of the medical substance to be infused into the target region and describing a maximum dose of the medical substance to be applied to the off-target region. Relationship information describes a relationship between a physical parameter of an infusion setup and a selected spatial distribution of the medical substance. Infusion setup information for the infusion is determined that describes a planned infusion setup and is based on the relationship information and information related to the target and off-target regions.

Method for determining an infusion parameter

Methods of delivering viral vectors, particularly recombinant adeno-associated virus (rAAV) virions, to the central nervous system (CNS) using convection enhanced delivery (CED) are provided. The rAAV virions include a nucleic acid sequence encoding a therapeutic polypeptide. The methods can be used for treating CNS disorders such as for treating Parkinson's Disease.

Methods of treating Parkinson's disease using viral vectors

Described herein are cannulas having a stepped exterior. Also described are methods of making and using these cannulas, for example to deliver one or more materials to the central nervous system of an animal.

Growing community of inventors

Oakland, CA, United States of America

Krystof Bankiewicz