Wisconsin Alumni Research Foundation

University of Chicago

Nutech Ventures

University of Leiden

Kristy Leigh Kounovsky-Shafer

David Charles Schwartz

Juan Jose De Pablo

Kyubong Jo

Konstantinos Dimitrios Potamousis

Theo Odijk

Juan Pablo Hernandez-Ortiz

Jocelyn Dolphin

April Vonderfecht

Cody Dean Masters

Devices, systems, and methods for en masse patterning of nucleic acid molecule structures are disclosed. The devices can include microchannels and nanoslits. The microchannels and nanoslits can be connected by parking chambers. The systems and methods can utilize the geometry of the devices in coordination with a voltage application routine to park nucleic acid molecules in the parking chambers and subsequently inject the nucleic acid molecules into the nanoslits. The methods can be utilized to present nucleic acid molecules in a fashion suitable for genomic analysis. The methods can also be utilized to provide size selection of the nucleic acid molecules.

System and method for en masse patterning of molecule structures

This disclosure relates to mesofluidic devices and methods for eluting and concentrating a plurality of nucleic acid molecules. The mesofluidic device includes a device frame having a bottom surface upon which is defined a first reservoir and the second reservoir. The first reservoir includes a first electrode, and the second reservoir includes a second electrode. The first and second electrodes are configured for electrical connection. The mesofluidic device includes an elongated channel extending between the first reservoir and the second reservoir. The mesofluidic device includes a first slot having a first slot width. The first slot is configured to receive an insert. The first slot intersects the elongated channel. The mesofluidic device includes a second slot having a second slot width. The second slot is configured to receive a separation material having a first porosity. The second slot intersects the elongated channel.

Devices and methods for eluting and concentrating large DNA molecules

Growing community of inventors

Kearney, NE, United States of America

Kristy Leigh Kounovsky-Shafer