Leo-pharma A/s

Kristoffer Maansson

Morten Dahl Sørensen

Patrick Stephen Johnson

Alan Stuart Jessiman

The present invention relates to a compound according to general formula (I) wherein X represents N or CH; Ris &#x2014;CN, (C-C)alkyl, (C-C)cycloalkyl, (3-7 membered)heterocycloalkyl, (5-6 membered)heteroaryl, (C-C)cycloalkyl(C-C)alkyl, (3-7 membered)heterocycloalkyl-(C-C)alkyl or (5-6 membered)heteroaryl-(C-C)alkyl; Ris halogen, cyano, (C-C)alkyl or (C-C)cycloalkyl; Ris halogen, cyano, (C-C)alkyl, (C-C)haloalkyl or (C-C)cycloalkyl; Ris (C-C)alkyl or (C-C)haloalkyl; Ris (C-C)alkyl, (C-C)cycloalkyl, (C-C)alkyl-(C-C)cycloalkyl, (C-C)cycloalkyl-(C-C)alkyl, (3-7 membered)heterocycloalkyl, phenyl, (5-6 membered)heteroaryl or &#x2014;OR. The invention further relates to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds and to intermediates for preparation of said compounds. 

Heteroaromatic modulators of the retinoid-related orphan receptor gamma

The present invention relates to a compound according to general formula (I) wherein X represents N or CH; Ris &#x2014;CN, (C-C)alkyl, (C-C)cycloalkyl, (3-7 membered)heterocycloalkyl, (5-6 membered)heteroaryl, (C-C)cycloalkyl(C-C)alkyl, (3-7 membered)heterocycloalkyl-(C-C)alkyl or (5-6 membered)heteroaryl-(C-C)alkyl; Ris halogen, cyano, (C-C)alkyl or (C-C)cycloalkyl; Ris halogen, cyano, (C-C)alkyl, (C-C)haloalkyl or (C-C)cycloalkyl; Ris (C-C)alkyl or (C-C)haloalkyl; Ris (C-C)alkyl, (C-C)cycloalkyl, (C-C)alkyl-(C-C)cycloalkyl, (C-C)cycloalkyl-(C-C)alkyl, (3-7 membered)heterocycloalkyl, phenyl, (5-6 membered)heteroaryl or &#x2014;OR. The invention further relates to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds and to intermediates for preparation of said compounds.

Growing community of inventors

Ballerup, Denmark

Kristoffer Maansson