University of Michigan

Kristoff Homan

Scott D Larsen

John J G Tesmer

Helen Waldschmidt

Michael William Wilson

John JG Tesmer

Disclosed herein are novel GRK inhibitors and methods for their use in treating or preventing heart disease, such as cardiac failure, cardiac hypertrophy, and hypertension. In particular, disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salt thereof, wherein the substituents are as described. 

G protein-coupled receptor kinase inhibitors and methods for use of the same

Disclosed herein are novel GRK2 inhibitors and methods for their use in treating or preventing heart disease, such as cardiac failure, cardiac hypertrophy, and hypertension. In particular, disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salt thereof: wherein the substituents are as described. 

Growing community of inventors

Newton, MA, United States of America

Kristoff Homan