Locus Pharmaceuticals, Inc.

Kristofer K Moffett

Younghee Lee

Bin Liu

Rupa S Shetty

Zenon D Konteatis

Bruce D Dorsey

Enrique Luis Michelotti

Martha Jean Kelly

Frank Peter Hollinger

Duyan Nguyen

Kevin J Moriarty

Eric Bruce Springman

Jennifer Lee Ludington

Wenchun Chao

Kevin J Moriarity

Jinming Zou

Ted Tsutomis Fujimoto

A compound of formula (I): wherein all symbols have the same meanings as defined in the specification; a salt thereof, a solvate thereof, an N-oxide thereof, or a prodrug thereof, has an Itk inhibitory activity, and is useful as a method for preventing and/or treating atopic dermatitis, and the like.

Aminopyrazine compounds

A compound of formula (I): wherein all symbols have the same meanings as defined in the specification; a salt thereof, a solvate thereof, an N-oxide thereof, or a prodrug thereof, has a Btk inhibitory activity, and is useful as a method for preventing and/or treating a rheumatoid arthritis, an autoimmune disease, a B cell lymphoma of cancer, and the like.

Pyrrolotriazine compounds

The present invention is directed to a compound having the formula wherein R, R, G, and Q are defined herein. The compounds of the present invention are useful as inhibitors of protein kinases such as MAP kinases, in particular p38 kinases. The present invention is also directed to compositions comprising a compound according to the above formula. The compounds and compositions described herein are useful for treating and preventing an inflammatory condition or disease. The present invention is also directed to a method of treating or preventing a protein kinase-mediated condition.

Urea inhibitors of MAP kinases

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Middletown, CT, United States of America

Kristofer K Moffett