University of Utah Research Foundation

Brigham Young University

Kristofer D Sinclair

David W Grainger

Amanda Elaine Brooks

Benjamin Delbert Brooks

Paul B Savage

Dustin Williams

Roy Drake Bloebaum

Bryan S Haymond

Benjamin Brooks

Amanda Brooks

In one aspect, the invention provides an implantable device comprising a uniform mixture of components including degradable polymer, inorganic bone particulate either natural or synthetic, a drug, and a soluble microporagen. In some embodiments, the uniform mixture further includes a soluble polymer macroporagen. In some embodiments, the uniform mixture is coated with an immobilized outer porous layer comprising or consisting of synthetic or natural inorganic bone granules. In further aspects, the invention provides an implantable device comprising a composite core of degradable polymer, bone, and a drug, and a coating comprising or consisting of microporous bone overlayer covering the degradable composite core.

Implantable devices for bone or joint defects

A medical device that includes a coating of a composite material that includes a polymeric material having a void structure and particulate ceragenin material (i.e., ceragenin particles) associated with the void structure. The average particle size of the ceragenin particles in the composite is in a range from 5 nm to 20 &#x3bc;m, 50 nm to 10 &#x3bc;m, 100 nm to 5 &#x39e;m, or 1 &#x3bc;m to 10 &#x3bc;m. The composite has a high loading of ceragenin particles (e.g., about 10% to about 25%, by weight). The composite has good polymer stability, the ability to release ceragenins from the ceragenin particles disposed in the composite over a sustained period of time at a characteristic elution rate, and the ability to kill large numbers of bacteria and other susceptible microbes over the sustained period of time.

Medical devices incorporating ceragenin-containing composites

Growing community of inventors

Salt Lake City, UT, United States of America

Kristofer D Sinclair