Flagship Pioneering Innovations V, Inc.

Kristine Yu

Yajie Niu

Randall William Shultz

Brian Prescott Fiske

Frank Anthony Skraly

John Patrick Casey, Jr

Barry Andrew Martin

John P Casey

Disclosed herein are compositions and methods for effecting alterations at a defined location in the genome of a non-epidermal plant cell. Further disclosed are methods for providing plants having a modified phenotype or a modified genome.

Methods of genetically altering a whole plant seed

Disclosed herein are compositions and methods for effecting alterations at a defined location in the genome of a plant cell or plant protoplast. Further disclosed are methods using an RNA-guided nuclease to alter a target nucleotide sequence in a cell or protoplast of a plant; embodiments of such methods include treatments with chemical or physical reagents or treatment of the cell or protoplast with a specific thermal regime, such as a heat treatment.

Methods of altering a target nucleotide sequence with an RNA-guided nuclease and a single guide RNA

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Cambridge, MA, United States of America

Kristine Yu