Merck + Co., Inc.

Kristine Prendergast

Mark E Fraley

Craig Alan Coburn

Randall W Hungate

M Katharine Holloway

Eric E Allen

Tomasz W Glinka

Robert B Nachbar

Stephen E deLaszlo

Compounds such as ##STR1## or pharmaceutically acceptable salts thereof, are HIV protease inhibitors. These compounds are useful in the prevention or treatment of infection by HIV and in the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.

HIV protease inhibitors useful for the treatment of AIDS

Macrocyclic compounds of general Structure I: ##STR1## Wherein M is C or N are angiotensin II receptor (A-II) antagonists useful in the treatment of certain cardiovascular dysfunctions and ocular hypertension.

Macrocycles incorporating quinazolinones

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Doylestown, PA, United States of America

Kristine Prendergast